NAA60 - N-alpha-acetyltransferase 60, NatF catalytic subunit Gene

Also Known as HAT4; NatF; NAT15; hNaa60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79903

About NAA60

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,443,611-3,486,963 (from NCBI)

This gene has 40 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 15.2), duodenum (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

NAA60 Products (9)

mRNA Protein Name
NM_001083600.3 NP_001077069.1 N-alpha-acetyltransferase 60 isoform a
NM_001083601.3 NP_001077070.1 N-alpha-acetyltransferase 60 isoform a
NM_001317093.1 NP_001304022.1 N-alpha-acetyltransferase 60 isoform b
NM_001317094.2 NP_001304023.1 N-alpha-acetyltransferase 60 isoform c
NM_001317095.2 NP_001304024.1 N-alpha-acetyltransferase 60 isoform d
NM_001317096.2 NP_001304025.1 N-alpha-acetyltransferase 60 isoform e
NM_001317097.2 NP_001304026.1 N-alpha-acetyltransferase 60 isoform f
NM_001317098.2 NP_001304027.1 N-alpha-acetyltransferase 60 isoform f
NM_024845.4 NP_079121.1 N-alpha-acetyltransferase 60 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
21981917 GOA
enables peptide alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
21750686 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
27320834 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in N-terminal peptidyl-methionine acetylation IDA
IDA: Inferred from direct assay
21750686 GOA
involved in N-terminal protein amino acid acetylation IDA
IDA: Inferred from direct assay
25732826 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
21981917 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
21981917 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
21981917 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA60 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (60 - 156)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 60

  • N-acetyltransferase 15 (GCN5-related, putative)

NAA60 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NAA60 Q9H7X0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
NAA60 Q9H7X0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
NAA60 Q9H7X0 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
NAA60 Q9H7X0 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra
NAA60 Q9H7X0 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scheuermann Disease

  • Scheuermann'S Disease

  • Spinal Osteochondrosis

  • Juvenile Osteochondrosis Of Spine

  • Familial Scheuermann Disease

  • Familial Scheuermann Juvenile Kyphosis

  • Familial Spinal Osteochondrosis

  • Scheuermann Juvenile Kyphosis

  • Juvenile Osteochondritis Of The Spine

  • Juvenile Osteochondrosis Of Scheurermann

  • Scheuermann'S Kyphosis

  • Sherman'S Disease

  • Juvenile Kyphosis

  • Scheuermann Kyphosis

  • [X]Spinal Osteochondrosis, Unspecified
Microphthalmia, Syndromic 1

  • MCOPS1

  • Lenz Microphthalmia Syndrome

  • Lenz Dysplasia

  • Mcops4

  • Syndromic Microphthalmia 1

  • Lenz Microphthalmia

  • Maa

  • Microphthalmia Or Anophthalmos With Associated Anomalies

  • Syndromic Microphthalmia Type 4

  • Microphthalmia, Syndromic 4

  • Microphthalmia, Syndromic 4, Formerly

  • Mcops4, Formerly

  • Anop1, Formerly

  • Maa, Formerly

  • Lenz Type Microphthalmia

  • Syndromic Microphthalmia 4

  • Microphthalmia Lenz Type

  • Microphthalmia Syndromic 1

  • Syndromic Microphthalmia Type 1

  • Microphthalmia Syndromic 4

  • Microphthalmia With Ankyloblepharon And Intellectual Disability

  • Microphthalmia, Lenz Type

  • Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

  • Microphthalmia, Syndromic, 1

  • Anop1

  • Microphthalmia, Syndromic, Type 1
Temple Syndrome

  • Uniparental Disomy, Maternal, Chromosome 14

  • Temple Syndrome Due To Paternal 14q32.2 Microdeletion

  • Paternal Del(14)(Q32.2)

  • Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

  • Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

  • Upd(14)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-156140 Naa50-IN-1 Inhibitor 99.94% Unkown
HY-RS08992 NAA60 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAA60 VGNC VGNC:84247
Mus musculus NAA60 MGD MGI:1922013
Canis familiaris NAA60 VGNC VGNC:84246
Macaca mulatta NAA60 VGNC VGNC:96720
Rattus norvegicus NAA60 RGD RGD:1308915
Felis catus NAA60 VGNC VGNC:80603