RAB2B - RAB2B, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84932

About RAB2B

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,459,020-21,476,959 (from NCBI)

This gene has 6 transcripts (splice variants), 114 orthologues and 68 paralogues. Ubiquitous expression in bone marrow (RPKM 6.9), testis (RPKM 6.8) and 25 other tissues.

Summary

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

RAB2B Products (2)

mRNA Protein Name
NM_001163380.2 NP_001156852.1 ras-related protein Rab-2B isoform 2
NM_032846.4 NP_116235.2 ras-related protein Rab-2B isoform 1

RAB2B Protein Structure

Ras

Ras: Ras family (8 - 168)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-2B

  • GTP-binding protein RAB2B

RAB2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAB2B Q8WUD1 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
25416956
Intra
RAB2B Q8WUD1 ICA1 Homo sapiens Q05084
Y2H Array
29892012
Intra
RAB2B Q8WUD1 GDI2 Homo sapiens P50395
Anti Tag CoIP
33961781
Intra
RAB2B Q8WUD1 GDI2 Homo sapiens P50395
Anti Tag CoIP
35271311
Intra
RAB2B Q8WUD1 FAM114A2 Homo sapiens Q9NRY5
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 FAM114A2 Homo sapiens Q9NRY5
Validated Y2H
32296183
Intra
RAB2B Q8WUD1 FAM114A2 Homo sapiens Q9NRY5
Y2H Array
32296183
Intra
RAB2B Q8WUD1 TBX19 Homo sapiens O60806
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 TBX19 Homo sapiens O60806
Y2H Array
32296183
Intra
RAB2B Q8WUD1 VRTN Homo sapiens Q9H8Y1
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 VRTN Homo sapiens Q9H8Y1
Validated Y2H
32296183
Intra
RAB2B Q8WUD1 VRTN Homo sapiens Q9H8Y1
Y2H Array
32296183
Intra
RAB2B Q8WUD1 GARIN1A Homo sapiens Q6NXP2-2
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 GARIN1A Homo sapiens Q6NXP2-2
Y2H Array
32296183
Intra
RAB2B Q8WUD1 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RAB2B Q8WUD1 GARIN4 Homo sapiens Q8IYT1
Y2H Array
32296183
Intra
RAB2B Q8WUD1 GARIN4 Homo sapiens Q8IYT1
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
RAB2B Q8WUD1 BLZF1 Homo sapiens Q9H2G9
Y2H Array
25416956
Intra
RAB2B Q8WUD1 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
RAB2B Q8WUD1 FAM114A1 Homo sapiens Q8IWE2
Validated Y2H
25416956
Intra
RAB2B Q8WUD1 FAM114A1 Homo sapiens Q8IWE2
Y2H Array
32296183
Intra
RAB2B Q8WUD1 FAM114A1 Homo sapiens Q8IWE2
Anti Tag CoIP
33961781
Intra
RAB2B Q8WUD1 FAM114A1 Homo sapiens Q8IWE2
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
RAB2B Q8WUD1 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RAB2B Q8WUD1 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
RAB2B Q8WUD1 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 STAMBPL1 Homo sapiens Q96FJ0
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 STAMBPL1 Homo sapiens Q96FJ0
Validated Y2H
32296183
Intra
RAB2B Q8WUD1 STAMBPL1 Homo sapiens Q96FJ0
Y2H Array
32296183
Intra
RAB2B Q8WUD1 TXNDC11 Homo sapiens Q6PKC3
Y2H Array
32296183
Intra
RAB2B Q8WUD1 TXNDC11 Homo sapiens Q6PKC3
Y2H Prey Pooling
32296183
Intra
RAB2B Q8WUD1 GARIN6 Homo sapiens Q8NEG0
Y2H Array
25416956
Intra
RAB2B Q8WUD1 GARIN6 Homo sapiens Q8NEG0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11542 RAB2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB2B MGD MGI:1923588
Macaca mulatta RAB2B VGNC VGNC:81530
Rattus norvegicus RAB2B RGD RGD:1309117
Bos taurus RAB2B VGNC VGNC:33638
Felis catus RAB2B VGNC VGNC:97588
Canis familiaris RAB2B VGNC VGNC:45272
Others RAB2B NCBI