LAIR1 Protein, Rhesus Macaque (HEK293, His)
Based on 1 Customer Validation
LAIR1 Protein is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. LAIR1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Rhesus Macaque
- Source: HEK293
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Speicherung:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biologische Aktivität
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biologische Aktivität
LAIR1 Protein is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self[1]. LAIR1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag.
LAIR1 Protein is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR1 Protein recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity[2][3].
Technical Parameters
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Species Rhesus Macaque
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Source HEK293
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Tag C-6*His
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Accession
A0A0U3SBU1 (Q22-Y165)
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Gene ID/
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Molecular Construction
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N-term
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LAIR1 (Q22-Y165)
Accession # A0A0U3SBU1 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305
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AA Sequence
QEGPLPRPSISAEPGTVIPPGRPVTIVCRGPAGVDQFRLEREGRSKFNDTKDVSQASPSESEARFRIDSVSEGNTRHYRCLYRKSTEWSQRSDYLDLVVKETSGDTDSPVTEPDSSAGPTQRPSDNSHNEHAPASQGLSAEHLY
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Predicted Molecular Mass
16.6 kDa
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Molecular Weight
Approximately 25-33 kDa, based on SDS-PAGE under reducing conditions.
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Reinheit
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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