Dynlt1 - dynein light chain Tctex-type 1 Gene

Also Known as AGS2; Tctex1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83462

Summary

Enables protein C-terminus binding activity. Involved in several processes, including negative regulation of mitochondrial membrane permeability; neuron projection development; and positive regulation of Rac protein signal transduction. Located in axonal growth cone; lamellipodium; and neuronal cell body. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Apr 2022]

Dynlt1 Products (1)

mRNA	Protein	Name
NM_031318.1	NP_112608.1	dynein light chain Tctex-type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12591166	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	15768038	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in axon development	IDA IDA: Inferred from direct assay	15992542	RGD
involved in cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22164227	RGD
involved in dendrite development	IDA IDA: Inferred from direct assay	15992542	RGD
involved in negative regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	22164227	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	15992542	RGD
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	15992542	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15992542	RGD
involved in regulation of cytoskeleton organization	IDA IDA: Inferred from direct assay	15992542	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	15992542	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	15992542	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15992542	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dynein light chain Tctex-type 1	T-complex testis-specific protein 1 homolog activator of G-protein signaling 2 t-complex testis expressed 1

Dynlt1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dynlt1	Q9Z336	Scn10a	Rattus norvegicus	Q62968	Y2H	12591166

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04092	DYNLT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dynlt1	NCBI	NCBI:6993