Scn10a - sodium voltage-gated channel alpha subunit 10 Gene

Also Known as PN3; Nav1.8; Na(V)1.8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29571

About Scn10a

Primary_assembly 8: 119,350,724-119,462,614 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 331 orthologues, 26 paralogues and is associated with 14 phenotypes. Biased expression in Heart (RPKM 8.7), Testes (RPKM 2.7) and 4 other tissues.

Summary

Enables voltage-gated Sodium Channel activity. Involved in odontogenesis of dentin-containing tooth; sensory perception of pain; and sodium ion transport. Located in axon. Is integral component of membrane. Part of clathrin complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Apr 2022]

Scn10a Products (1)

mRNA Protein Name
NM_017247.2 NP_058943.2 sodium channel protein type 10 subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12050667 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
26187311 RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
26187311 RGD
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
8538791 RGD
Biological Process GO Annotation Evidence References Source
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
21640979 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
8538791 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21118538 RGD
part of clathrin complex IDA
IDA: Inferred from direct assay
15797711 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19162133 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
19162133 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn10a Protein Structure

Ion_trans

Ion_trans: pfam00520 (128 - 405)

Na_trans_cytopl

Na_trans_cytopl: cl13384 (486 - 613)

Ion_trans

Ion_trans: pfam00520 (662 - 892)

Na_trans_assoc

Na_trans_assoc: pfam06512 (902 - 1147)

Ion_trans

Ion_trans: pfam00520 (1151 - 1427)

Na_channel_gate

Na_channel_gate: cd13433 (1419 - 1471)

Ion_trans

Ion_trans: pfam00520 (1475 - 1732)

  • 0
  • 400
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  • 1600
  • 1956 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 10 subunit alpha

  • peripheral nerve sodium channel 3

  • sensory neuron sodium channel

  • sodium channel protein type X subunit alpha

  • sodium channel type X alpha polypeptide

  • sodium channel voltage-gated type X alpha polypeptide

  • sodium channel, voltage-gated, type 10, alpha polypeptide

  • sodium channel, voltage-gated, type X, alpha subunit

  • voltage-gated sodium channel subunit alpha Nav1.8

Scn10a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Scn10a Q62968 S100a10 Rattus norvegicus P05943
Y2H
12050667
Intra
Scn10a Q62968 Prx Rattus norvegicus Q63425
Y2H
12591166
Intra
Scn10a Q62968 Dynlt1 Rattus norvegicus Q9Z336
Anti Bait CoIP
12591166
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12519 SCN10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12520 Scn10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12521 Scn10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn10a NCBI NCBI:6336