SCN10A - sodium voltage-gated channel alpha subunit 10 Gene

Also Known as PN3; SNS; FEPS2; Nav1.8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6336

About SCN10A

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,696,807-38,816,217 (from NCBI)

This gene has 3 transcripts (splice variants), 331 orthologues, 26 paralogues and is associated with 7 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated Sodium Channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

SCN10A Products (6)

mRNA	Protein	Name
NM_001293306.2	NP_001280235.2	sodium channel protein type 10 subunit alpha isoform 2
NM_001293307.2	NP_001280236.2	sodium channel protein type 10 subunit alpha isoform 3
NM_006514.4	NP_006505.4	sodium channel protein type 10 subunit alpha isoform 1
XM_011533993.3	XP_011532295.1	sodium channel protein type 10 subunit alpha isoform X2
XM_005265371.4	XP_005265428.1	sodium channel protein type 10 subunit alpha isoform X1
XM_011533994.3	XP_011532296.1	sodium channel protein type 10 subunit alpha isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	24998131	GOA
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	9839820	GOA
enables voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	23115331	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in AV node cell action potential	IMP IMP: Inferred from mutant phenotype	24998131	GOA
involved in bundle of His cell action potential	IMP IMP: Inferred from mutant phenotype	24998131	GOA
involved in membrane depolarization during action potential	IMP IMP: Inferred from mutant phenotype	23115331	GOA
involved in regulation of atrial cardiac muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	20062061	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	20062061	GOA
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	20062061	GOA
involved in regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	9839820	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	9839820	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	23115331	GOA
part of voltage-gated sodium channel complex	IDA IDA: Inferred from direct assay	9839820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCN10A Protein Structure

Ion_trans

Na_trans_assoc

Ion_trans

0
400
800
1200
1600
1956 a.a.

Protein Preferred Names	Protein Names
sodium channel protein type 10 subunit alpha	peripheral nerve sodium channel 3 sensory neuron sodium channel sodium channel protein type X subunit alpha sodium channel, voltage-gated, type X, alpha polypeptide sodium channel, voltage-gated, type X, alpha subunit voltage-gated sodium channel subunit alpha Nav1.8

Related Diseases

Diseases	Alias
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Laurence-Moon Syndrome	LNMS Laurence-Moon-Biedl Syndrome
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Episodic Pain Syndrome, Familial, 2	FEPS2 Familial Episodic Pain Syndrome 2
Erythromelalgia	Primary Erythromelalgia Erythermalgia Primary Erythermalgia Mitchell Disease Familial Erythromelalgia
Neuroma
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Bladder Clear Cell Adenocarcinoma	Bladder Mesonephric Adenocarcinoma Clear Cell Adenocarcinoma Of Bladder
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Pain Agnosia	Analgesia
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Episodic Pain Syndrome, Familial, 3	FEPS3 Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement Familial Episodic Pain Syndrome 3
Diabetic Neuropathy	Diabetic Neuropathies
Generalized Epilepsy With Febrile Seizures Plus	Gefs+ Genetic Epilepsy With Febrile Seizures Plus Generalized Epilepsy With Febrile Seizures-Plus Genetic Epilepsy With Febrile Seizures-Plus Epilepsy, Generalized, With Febrile Seizures Plus
Brugada Syndrome 1	BRGDA1 Sudden Unexplained Nocturnal Death Syndrome Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sunds Brugada Syndrome, Type 1 Brugada Syndrome
Penile Cancer	Penis Carcinoma Penile Neoplasm Penile Carcinoma Penile Neoplasms Malignant Neoplasm Of Penis Ca Penis Malignant Neoplasm Of Body Of Penis Malignant Penile Tumor Penile Ca Carcinoma Of Penis
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Penile Disease	Penile Diseases
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Gastric Diffuse Adenocarcinoma	Diffuse Gastric Adenocarcinoma Carcinoma, Diffuse Type
Familial Episodic Pain Syndrome	Feps
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Neuropathy	Peripheral Neuropathy Peripheral Neuropathies
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Smei Severe Myoclonic Epilepsy In Infancy Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Developmental And Epileptic Encephalopathy, 6 Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Sinoatrial Node Disease	Sa Node Sinuatrial Node Sinus Node Dysfunction
Indifference To Pain, Congenital, Autosomal Recessive	Asymbolia For Pain Neuropathy, Hereditary Sensory And Autonomic, Type Iid CIP Insensitivity To Pain, Channelopathy-Associated Congenital Analgesia, Autosomal Recessive Insensitivity To Pain, Congenital Congenital Insensitivity To Pain-Anosmia-Neuropathic Arthropathy Scn9a-Related Congenital Insensitivity To Pain Channelopathy-Associated Insensitivity To Pain Congenital Analgesia Autosomal Recessive
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Causalgia	Complex Regional Pain Syndrome, Type Ii Complex Regional Pain Syndrome Type 2
Sick Sinus Syndrome	Sinus Node Dysfunction Sinus Node Disease Sinus Node Infection Snd Sss Snd - [Sinus Node Dysfunction] Sinoatrial Node Dysfunction Sss - [Sick Sinus Syndrome] Sick Sinus Sick Sinus Tachycardia
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Linitis Plastica	Leather-Bottle Stomach
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Paroxysmal Extreme Pain Disorder	PEPD Familial Rectal Pain Pexpd Submandibular, Ocular, And Rectal Pain With Flushing Pain, Submandibular, Ocular, And Rectal, With Flushing Rectal Pain, Familial Submandibular, Ocular And Rectal Pain With Flushing Familial Rectal Syndrome Frp Pain Disorder, Paroxysmal, Extreme
Sodium Channelopathy-Related Small Fiber Neuropathy
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1 Cardiomyopathy, Hypertrophic, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS12519	SCN10A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12520	Scn10a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12521	Scn10a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCN10A	VGNC	VGNC:34343
Mus musculus	SCN10A	MGD	MGI:108029
Felis catus	SCN10A	VGNC	VGNC:64918
Canis familiaris	SCN10A	VGNC	VGNC:45913
Rattus norvegicus	SCN10A	RGD	RGD:3629
Macaca mulatta	SCN10A	VGNC	VGNC:76980
Others	SCN10A	NCBI