SCN10A - sodium voltage-gated channel alpha subunit 10 Gene

Homo sapiens

Also known as PN3; SNS; FEPS2; Nav1.8

Gene ID: 6336 | Gene type: protein coding

About SCN10A

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,696,807-38,816,217 (from NCBI)

This gene has 3 transcripts (splice variants), 331 orthologues, 26 paralogues and is associated with 7 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated Sodium Channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

SCN10A Products(6)

mRNA	Protein	Name
NM_001293306.2	NP_001280235.2	sodium channel protein type 10 subunit alpha isoform 2
NM_001293307.2	NP_001280236.2	sodium channel protein type 10 subunit alpha isoform 3
NM_006514.4	NP_006505.4	sodium channel protein type 10 subunit alpha isoform 1
XM_011533993.3	XP_011532295.1	sodium channel protein type 10 subunit alpha isoform X2
XM_005265371.4	XP_005265428.1	sodium channel protein type 10 subunit alpha isoform X1
XM_011533994.3	XP_011532296.1	sodium channel protein type 10 subunit alpha isoform X3

SCN10A Protein Structure

Ion_trans

Na_trans_assoc

Ion_trans

0
400
800
1200
1600
1956 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 10 subunit alpha

peripheral nerve sodium channel 3	sensory neuron sodium channel
sodium channel protein type X subunit alpha	sodium channel, voltage-gated, type X, alpha polypeptide
sodium channel, voltage-gated, type X, alpha subunit	voltage-gated sodium channel subunit alpha Nav1.8

Related Diseases

Diseases

Alias

Penile Benign Neoplasm

Neoplasm Of Penis	Penile Tumor
Cancer Of Penis	Carcinoma Of Penis
Malignant Neoplasm Of Penis, Unspecified	Malignant Neoplasm Of Penis, Part Unspecified
Malignant Tumour Of Penis	Penile Cancer
Primary Malignant Neoplasm Of Penis	Malignant Neoplasm Of Skin Of Penis Nos

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Laurence-Moon Syndrome

LNMS	Laurence-Moon-Biedl Syndrome

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Episodic Pain Syndrome, Familial, 2

FEPS2

Familial Episodic Pain Syndrome 2

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Neuroma

Diabetic Polyneuropathy

Diabetes Mellitus With Polyneuropathy	Polyneuropathy In Diabetes
Diabetic Polyneuropathies	Diabetic Neuropathy Nos

Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Pain Agnosia

Analgesia

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Episodic Pain Syndrome, Familial, 3

FEPS3	Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement
Familial Episodic Pain Syndrome 3

Diabetic Neuropathy

Diabetic Neuropathies

Generalized Epilepsy With Febrile Seizures Plus

Gefs+	Genetic Epilepsy With Febrile Seizures Plus
Generalized Epilepsy With Febrile Seizures-Plus	Genetic Epilepsy With Febrile Seizures-Plus
Epilepsy, Generalized, With Febrile Seizures Plus

Brugada Syndrome 1

BRGDA1	Sudden Unexplained Nocturnal Death Syndrome
Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome	Sunds
Brugada Syndrome, Type 1	Brugada Syndrome

Penile Cancer

Penis Carcinoma	Penile Neoplasm
Penile Carcinoma	Penile Neoplasms
Malignant Neoplasm Of Penis	Ca Penis
Malignant Neoplasm Of Body Of Penis	Malignant Penile Tumor
Penile Ca	Carcinoma Of Penis

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Hard Palate Cancer

Malignant Neoplasm Of Hard Palate	Malignant Tumor Of Hard Palate
Malignant Tumour Of Hard Palate

Penile Disease

Penile Diseases

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes	Reflex Sympathetic Dystrophy
Crps

Gastric Diffuse Adenocarcinoma

Diffuse Gastric Adenocarcinoma

Carcinoma, Diffuse Type

Familial Episodic Pain Syndrome

Feps

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Neuropathy

Peripheral Neuropathy

Peripheral Neuropathies

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Smei
Severe Myoclonic Epilepsy In Infancy	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Dee6	Developmental And Epileptic Encephalopathy 6
Early Infantile Epileptic Encephalopathy 6	Myoclonic Epilepsy, Severe, Of Infancy
Sme	Severe Myoclonus Epilepsy Of Infancy
Borderline Smei	Smeb
Smeb-M	Smeb-O
Smeb-Sw	Smei-Borderland
Smei-Borderland More Than One Feature	Smei-Borderland-Myoclonic Seizures
Smei-Borderland-Spike Wave	Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures
ICEGTC	Developmental And Epileptic Encephalopathy, 6
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction	Autonomic Nervous System Disorders
Autonomic Nervous System Disorder	Autonomic Nervous System Diseases
Abnormality Of The Autonomic Nervous System

Sinoatrial Node Disease

Sa Node	Sinuatrial Node
Sinus Node Dysfunction

Indifference To Pain, Congenital, Autosomal Recessive

Asymbolia For Pain	Neuropathy, Hereditary Sensory And Autonomic, Type Iid
CIP	Insensitivity To Pain, Channelopathy-Associated
Congenital Analgesia, Autosomal Recessive	Insensitivity To Pain, Congenital
Congenital Insensitivity To Pain-Anosmia-Neuropathic Arthropathy	Scn9a-Related Congenital Insensitivity To Pain
Channelopathy-Associated Insensitivity To Pain	Congenital Analgesia Autosomal Recessive

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Causalgia

Complex Regional Pain Syndrome, Type Ii

Complex Regional Pain Syndrome Type 2

Sick Sinus Syndrome

Sinus Node Dysfunction	Sinus Node Disease
Sinus Node Infection	Snd
Sss	Snd - [Sinus Node Dysfunction]
Sinoatrial Node Dysfunction	Sss - [Sick Sinus Syndrome]
Sick Sinus	Sick Sinus Tachycardia

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Linitis Plastica

Leather-Bottle Stomach

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Sodium Channelopathy-Related Small Fiber Neuropathy

Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Hypertrophic Cardiomyopathy	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Fhc
Cardiomyopathy, Hypertrophic, Familial, Type 1	Cardiomyopathy, Hypertrophic, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12519	SCN10A Human Pre-designed siRNA Set A	/	Unkown
HY-RS12520	Scn10a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12521	Scn10a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCN10A	VGNC	VGNC:34343
Mus musculus	SCN10A	MGD	MGI:108029
Felis catus	SCN10A	VGNC	VGNC:64918
Canis familiaris	SCN10A	VGNC	VGNC:45913
Rattus norvegicus	SCN10A	RGD	RGD:3629
Macaca mulatta	SCN10A	VGNC	VGNC:76980