Prx - periaxin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78960

Summary

Involved in axon ensheathment and nerve development. Located in myelin sheath. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin). [provided by Alliance of Genome Resources, Apr 2022]

Prx Products (1)

mRNA Protein Name
NM_023976.2 NP_076466.2 periaxin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12591166 RGD
Biological Process GO Annotation Evidence References Source
involved in axon ensheathment IEP
IEP: Inferred from expression pattern
8155317 RGD
involved in nerve development IEP
IEP: Inferred from expression pattern
8155317 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

periaxin

Prx Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Prx Q63425 Scn10a Rattus norvegicus Q62968
Anti Bait CoIP
12591166
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-14848 Naluzotan 98.05% Phase 3
HY-15472 PRX-08066 97.46% Phase 2
HY-106385 PRX-03140 Agonist / Phase 2
HY-14559 PRX-07034 hydrochloride Antagonist 98.97% Phase 1
HY-100171A PRX933 Agonist / Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99405 Prasinezumab Inhibitor 99.90% Phase 3
HY-P99554 Topsalysin / Phase 3
HY-P990708 Bizaxofusp / Phase 2
HY-P99543 Tulinercept Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14848A Naluzotan hydrochloride 99.63% Unkown
HY-100171 PRX933 hydrochloride Agonist / Unkown
HY-15472A PRX-08066 maleate / Unkown
HY-158198 PRXS571 Modulator / Unkown
HY-19846 VRX-03011 Agonist / Unkown
HY-RS11079 PRDX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11265 PRX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W671129 Frenolicin B Inhibitor / Unkown
HY-177477 2,5-Epidithia-3,6-dioxopiperazine / Unkown
HY-RS17938 Prx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24409 Prx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991704 Moponetug Inhibitor 98.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prx NCBI NCBI:57716