NDSB-195
Based on 1 Customer Validation
NDSB-195 is protein stabilizer that enhances the dynamics of the β4-α2 loop of ubiquitin. NDSB-195 stabilizes Saccharomyces cerevisiae ubiquitin against guanidium chloride denaturation, increasing the onset temperature of heat denaturation in the presence of the denaturant.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 160255-06-1
- Formula: C7H17NO3S
- Molecular Weight:195.28
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NDSB-195 (0.5-1.0 M) stabilizes S. cerevisiae ubiquitin against guanidium chloride-induced denaturation, as shown by preserved secondary structure and an increased heat denaturation onset temperature of 70°C with 0.5 M NDSB-195[1].
NDSB-195 (0-500 mM) selectively reduces the amide proton NMR line width of Gly53 in yeast ubiquitin in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 160255-06-1
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Appearance Solid
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Molecular Weight 195.28
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Formula C7H17NO3S
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Color White to off-white
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SMILES
O=S(CCC[N+](C)(CC)C)([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 125 mg/mL (640.11 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.1209 mL | 25.6043 mL | 51.2085 mL | 128.0213 mL |
| 5 mM | 1.0242 mL | 5.1209 mL | 10.2417 mL | 25.6043 mL | |
| 10 mM | 0.5121 mL | 2.5604 mL | 5.1209 mL | 12.8021 mL | |
| 15 mM | 0.3414 mL | 1.7070 mL | 3.4139 mL | 8.5348 mL | |
| 20 mM | 0.2560 mL | 1.2802 mL | 2.5604 mL | 6.4011 mL | |
| 25 mM | 0.2048 mL | 1.0242 mL | 2.0483 mL | 5.1209 mL | |
| 30 mM | 0.1707 mL | 0.8535 mL | 1.7070 mL | 4.2674 mL | |
| 40 mM | 0.1280 mL | 0.6401 mL | 1.2802 mL | 3.2005 mL | |
| 50 mM | 0.1024 mL | 0.5121 mL | 1.0242 mL | 2.5604 mL | |
| 60 mM | 0.0853 mL | 0.4267 mL | 0.8535 mL | 2.1337 mL | |
| 80 mM | 0.0640 mL | 0.3201 mL | 0.6401 mL | 1.6003 mL | |
| 100 mM | 0.0512 mL | 0.2560 mL | 0.5121 mL | 1.2802 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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