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Cat. No.: HY-184226

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ASAP-0031651

ASAP-0031651 is an orally active inhibitor of Zika virus NS2B-NS3 protease. ASAP-0031651 binds the active site of virus NS2B-NS3 protease to inhibit its function. ASAP-0031651 exerts antiviral activity against Zika virus. ASAP-0031651 can be used for the research of virus infection.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₀F₅N₃O
Molecular Weight:413.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ASAP-0031651 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

ASAP-0031651 potently inhibits ZIKV NS2B-NS3 protease with a K_i of 7.8 nM^[1].
ASAP-0031651 inhibits ZIKV replication in VeroE6 cells with an EC₅₀ of 0.45 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 413.38
Formula C₂₀H₂₀F₅N₃O
SMILES

CC1=CC(C(C(NCC(F)F)=O)NC2=CC(CNC3)=C3C=C2)=CC(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kenton NT, et al. Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease. bioRxiv [Preprint]. 2025 Jun 20:2025.06.19.660642. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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