MYBBP1A - MYB binding protein 1a Gene

Also Known as P160; PAP2; Pol5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10514

About MYBBP1A

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,538,904-4,555,384 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MYBBP1A Products (2)

mRNA Protein Name
NM_001105538.2 NP_001099008.1 myb-binding protein 1A isoform 1
NM_014520.4 NP_055335.2 myb-binding protein 1A isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
21471221 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
21471221 GOA
involved in positive regulation of anoikis IMP
IMP: Inferred from mutant phenotype
23388179 GOA
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: Inferred from direct assay
16603771 GOA
acts upstream of negative effect regulation of G1 to G0 transition IMP
IMP: Inferred from mutant phenotype
21471221 GOA
Cellular Component GO Annotation Evidence References Source
part of B-WICH complex IDA
IDA: Inferred from direct assay
16603771 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
21471221 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21471221 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYBBP1A Protein Structure

DNA_pol_phi

DNA_pol_phi: DNA polymerase phi (70 - 836)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1328 a.a.
Protein Preferred Names Protein Names

myb-binding protein 1A

  • MYB binding protein (P160) 1a

MYBBP1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P81642 MYBBP1A Antibody (YA1387) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

  • CMTX3

  • Charcot-Marie-Tooth Disease X-Linked Recessive 3

  • Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3

  • Cmt3x

  • X-Linked Charcot-Marie-Tooth Disease Type 3

  • Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3

  • Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08870 MYBBP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21246 Mybbp1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27763 Mybbp1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MYBBP1A VGNC VGNC:43519
Macaca mulatta MYBBP1A VGNC VGNC:75090
Felis catus MYBBP1A VGNC VGNC:68370
Rattus norvegicus MYBBP1A RGD RGD:62062
Bos taurus MYBBP1A VGNC VGNC:31777
Mus musculus MYBBP1A MGD MGI:106181
Others MYBBP1A NCBI