MAPK15 - mitogen-activated protein kinase 15 Gene

Also Known as ERK7; ERK8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 225689

About MAPK15

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,716,349-143,722,458 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 197 orthologues and 19 paralogues. Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues.

Summary

Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

MAPK15 Products (10)

mRNA	Protein	Name
XM_011516927.3	XP_011515229.1	mitogen-activated protein kinase 15 isoform X3
XM_011516925.3	XP_011515227.1	mitogen-activated protein kinase 15 isoform X1
XM_047421568.1	XP_047277524.1	mitogen-activated protein kinase 15 isoform X6
XM_047421567.1	XP_047277523.1	mitogen-activated protein kinase 15 isoform X5
XR_001745493.2
XM_047421566.1	XP_047277522.1	mitogen-activated protein kinase 15 isoform X4
XM_011516928.3	XP_011515230.1	mitogen-activated protein kinase 15 isoform X7
XM_011516926.3	XP_011515228.1	mitogen-activated protein kinase 15 isoform X2
XR_001745494.2
NM_139021.3	NP_620590.2	mitogen-activated protein kinase 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	11875070	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20733054	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	19166846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16624805	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	26595526	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	19166846	GOA
involved in dopamine uptake	IDA IDA: Inferred from direct assay	28842414	GOA
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	21847093	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24618899	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20638370	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20733054	GOA
acts upstream of positive regulation of telomere maintenance	IDA IDA: Inferred from direct assay	21531765	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21531765	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11875070	GOA
involved in protein localization to ciliary transition zone	IMP IMP: Inferred from mutant phenotype	29021280	GOA
involved in regulation of COPII vesicle coating	IMP IMP: Inferred from mutant phenotype	24618899	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	22948227	GOA
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	29021280	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	24618899	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	22948227	GOA
NOT located in axoneme	IDA IDA: Inferred from direct assay	29021280	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	29021280	GOA
located in centriole	IDA IDA: Inferred from direct assay	29021280	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	29021280	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20638370	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20638370	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK15 Protein Structure

Pkinase

0
100
200
300
400
500
544 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 15	ERK-7 ERK-8 MAP kinase 15 MAPK 15 extracellular regulated kinase 8 delta extracellular signal-regulated kinase 7 extracellular signal-regulated kinase 8

MAPK15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK15	Q8TD08	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MAPK15	Q8TD08	CDK2	Homo sapiens	P24941	Anti Tag CoIP	25852190

Cross: Cross-species interaction Intra: Intraspecies interaction

MAPK15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86863	ERK8 Antibody (YA6556)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hemangioma Of Subcutaneous Tissue	Angioma Of The Subcutaneous Tissue Subcutaneous Haemangioma Subcutaneous Hemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-135906	CK2/ERK8-IN-1	99.0%	Unkown
HY-RS08110	MAPK15 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08111	Mapk15 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08112	Mapk15 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAPK15	VGNC	VGNC:31217
Canis familiaris	MAPK15	VGNC	VGNC:42996
Macaca mulatta	MAPK15	VGNC	VGNC:74570
Mus musculus	MAPK15	MGD	MGI:2652894
Rattus norvegicus	MAPK15	RGD	RGD:628675
Others	MAPK15	NCBI