Slc39a8 - solute carrier family 39 (metal ion transporter), member 8 Gene

Also Known as Zip8; ZIP-8; BIGM103; 4933419D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67547

Summary

Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in bicarbonate transport; cellular transition metal ion homeostasis; and ion transmembrane transport. Acts upstream of or within cadmium ion transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; metanephros; and reproductive system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc39a8 Products (3)

mRNA Protein Name
NM_001135149.1 NP_001128621.1 metal cation symporter ZIP8 precursor
NM_001135150.1 NP_001128622.1 metal cation symporter ZIP8 precursor
NM_026228.5 NP_080504.3 metal cation symporter ZIP8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoatomic cation:bicarbonate symporter activity IDA
IDA: Inferred from direct assay
16638970 MGI
enables zinc:bicarbonate symporter activity IDA
IDA: Inferred from direct assay
18037372 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24529376 MGI
acts upstream of arginine metabolic process IMP
IMP: Inferred from mutant phenotype
28481222 MGI
involved in bicarbonate transport IDA
IDA: Inferred from direct assay
16638970 MGI
acts upstream of or within cadmium ion transmembrane transport IDA
IDA: Inferred from direct assay
15722412 MGI
involved in cadmium ion transmembrane transport IDA
IDA: Inferred from direct assay
16638970 MGI
involved in cadmium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
30015240 MGI
acts upstream of cartilage homeostasis IMP
IMP: Inferred from mutant phenotype
24529376 MGI
acts upstream of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
29337306 MGI
involved in intracellular manganese ion homeostasis IMP
IMP: Inferred from mutant phenotype
28481222 MGI
involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
24529376 MGI
involved in iron ion import across plasma membrane IDA
IDA: Inferred from direct assay
22898811 MGI
involved in iron ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
30015240 MGI
acts upstream of leukocyte adhesion to arterial endothelial cell IMP
IMP: Inferred from mutant phenotype
30015240 MGI
involved in manganese ion transmembrane transport IDA
IDA: Inferred from direct assay
16638970 MGI
involved in manganese ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28481222 MGI
involved in mercury ion transport IDA
IDA: Inferred from direct assay
16638970 MGI
involved in plasma membrane selenite transport IDA
IDA: Inferred from direct assay
27166256 MGI
acts upstream of protein N-linked glycosylation IMP
IMP: Inferred from mutant phenotype
28481222 MGI
acts upstream of regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
29337306 MGI
involved in zinc ion import across plasma membrane IDA
IDA: Inferred from direct assay
18037372 MGI
involved in zinc ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
29337306 MGI
involved in zinc ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24529376 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16638970 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15722412 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metal cation symporter ZIP8

  • Zrt- and Irt-like protein 8

  • zinc transporter ZIP8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179571 ZIP14-IN-1 Inhibitor 99.82% Unkown
HY-RS13239 SLC39A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16232 Slc39a8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28561 Slc39a8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc39a8 NCBI NCBI:64116