HCN2-IN-5
HCN2-IN-5 is a HCN2 ion channel inhibitor with an IC50 of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders.
For research use only. We do not sell to patients.
- CAS No.: 3080808-86-9
- Formula: C21H18ClN5O4S
- Molecular Weight:471.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HCN2 9 nM (IC50) |
HCN4 376 nM (IC50) |
HCN1 >33750 nM (IC50) |
HCN2-IN-5 (Compound 22) potently inhibits human HCN2 channels with an IC50 of 9 nM, inhibits human HCN4 channels with an IC50 of 376 nM, and does not significantly inhibit human HCN1 channels (IC50 >33750 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3080808-86-9
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Molecular Weight 471.92
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Formula C21H18ClN5O4S
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SMILES
O=C(C1=CC=NS1)NC2=NN(CC(C)OC)C3=NC=C(C4=C(Cl)C5=C(OCO5)C=C4)C=C23
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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