Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus

  • Bioorg Med Chem Lett. 2013 Jul 15;23(14):4258-62. doi: 10.1016/j.bmcl.2013.04.052.
Yanming Du  1 ,  Hong Ye ,  Fang Guo ,  Lijuan Wang ,  Tina Gill ,  Noshena Khan ,  Andrea Cuconati ,  Ju-Tao Guo ,  Timothy M Block ,  Jinhong Chang ,  Xiaodong Xu
Affiliations
  • 1. Institute for Hepatitis and Virus Research, 3805 Old Easton Road, Doylestown, PA 18902, USA. [email protected]
PMID: 23747225 DOI: 10.1016/j.bmcl.2013.04.052
Abstract

Novel N-alkyldeoxynojirimycins (NADNJs) based on our previous lead 3 were designed, synthesized and tested in metabolic assays and in virus cultures. NADNJs containing terminal tertiary benzamide, sulfonamide, urea, and Oxazolidinone moieties were discovered to have improved metabolic stability compared to 3, while maintaining submicromolar EC50 against BVDV and Tacaribe virus; and low cytotoxicity.