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Cat. No.: HY-N19733

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2′,3′-Dihydroxypuberulin

2′,3′-Dihydroxypuberulin is a naturally derived inhibitor of the FcεRI β-chain with FcεRI expression inhibitory activity in mast cells. 2′,3′-Dihydroxypuberulin suppresses the mRNA level of the FcεRI β-chain, blocks the assembly of the FcεRI tetramer, and reduces the cell surface expression level of FcεRI. 2′,3′-Dihydroxypuberulin can be used in studies related to type I allergic diseases.

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CAS No.: 79147-77-6
Formule: C₁₆H₂₀O₇
Masse moléculaire:324.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

2′,3′-Dihydroxypuberulin Chemical Structure

CAS No.: 79147-77-6

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Activité biologique

Description

In Vitro

2′,3′-Dihydroxypuberulin (compound 1) (30 μg/mL; 72 h) inhibits FcεRI surface expression on HMC-1 human mast cells by 49.0%, and its absolute configuration does not affect this activity^[2].
2′,3′-Dihydroxypuberulin (50-100 μM; 36 h) significantly down-regulates FcεRI β-chain mRNA expression without altering α-chain or γ-chain mRNA levels in HMC-1 human mast cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:

human mast cell line HMC-1
Concentration:

50, 100 μM
Incubation Time:

36 h
Result:

Suppressed FcεRI β-chain mRNA expression to ~85% of vehicle control levels, while α-chain and γ-chain mRNA levels remained near 95-98% of vehicle control (100 μM).
Suppressed FcεRI β-chain mRNA expression to ~60% of vehicle control, while α-chain and γ-chain mRNA levels remained near 90-95% of vehicle control (50 μM).

Chemical Information

CAS No. 79147-77-6
Masse moléculaire 324.33
Formule C₁₆H₂₀O₇
SMILES

COC1=C2C(C=CC(O2)=O)=CC(OC)=C1OCC(O)C(C)(O)C
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Magalhães AF, et al. Coumarins from Pterocaulon balansae and P. lanatum. Phytochemistry, 1981, 20(6):1369-1371.

[2]. Tamura S, et al. Inhibitor for FcεRI expression on mast cell from Verbasucum thapsus L. Bioorganic & medicinal chemistry letters. 2018 Nov 01;28(20):3342-3345. [Content Brief]

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2′,3′-Dihydroxypuberulin

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2′,3′-Dihydroxypuberulin

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Chemical Information

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Références

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2′,3′-Dihydroxypuberulin Related Classifications

HY-N19733 Related Classifications