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Cat. No.: HY-181113

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ALK-IN-34

ALK-IN-34 is an Anaplastic Lymphoma Kinase (ALK) inhibitor with an IC₅₀ of 0.26 μM. ALK-IN-34 demonstrates antiproliferative activity against lung cancer cells and gastric adenocarcinoma cells.

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Formule: C₂₅H₂₁N₃O
Masse moléculaire:379.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

ALK-IN-34 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

ALK-IN-34 (compound 8c) (1-100 μM; 72 h) potently inhibits proliferation of Karpas 299 cells (IC₅₀ = 2.17 μM) and H2228 cells (IC₅₀ = 6.02 μM), with lower potency against A549 and AGS cells^[1].
ALK-IN-34 (10 μM) shows greater selectivity towards ALK but also significantly inhibits EGFR and VEGFR2 kinases at 10 μM^[1].
ALK-IN-34 has lower toxicity towards L929 normal cells (IC₅₀ = 102.2 μM) compared to Karpas 299 cancer cells, with a selectivity index of 47.09^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Karpas 299 (NPM-ALK-positive ALCL), H2228 (EML4-ALK-positive NSCLC), A549 (ALK-negative NSCLC), AGS (gastric adenocarcinoma)
Concentration:

1, 5, 10, 25, 50, 100 μM
Incubation Time:

72 h
Result:

Inhibited proliferation of Karpas 299 cells with an IC₅₀ of 2.17 μM, H2228 cells with an IC₅₀ of 6.02 μM, A549 cells with an IC₅₀ of 41 μM, and AGS cells with an IC₅₀ of 45.8 μM.

Chemical Information

Masse moléculaire 379.45
Formule C₂₅H₂₁N₃O
SMILES

COC(C=C1)=CC=C1C2=C3C(C4=CC=CC=C4CC3)=NC(NC5=CC=CC=C5)=N2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Saravanakumar N, et al. Combined in silico and in vitro cytotoxic profiling of novel quinazoline derivatives targeting anaplastic lymphoma kinase for lung cancer therapy. Bioorg Chem. 2026;170:109450. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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