475473-26-8
475473-26-8
Chemical Structure
CORM-3
- CAS No.: 475473-26-8
- Formula:C5H4ClNO5Ru
- Molecular Weight:294.61
InChIKey: BICHHHDSEZXKNN-UHFFFAOYSA-L
SMILES: O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O
Biological Activity: CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].
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CORM-3 | 97.5% | CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation. | ||||||||||||||||||||
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References
- [1]. Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60. [Content Brief]
- [2]. Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493(2):957-963. [Content Brief]
- [3]. Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2)-induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39. [Content Brief]
Keywords
