Dihydrocoptisine
Dihydrocoptisine is a benzylisoquinoline alkaloid that can be isolated from the methanolic extract of the whole plant of Argemone mexicana L. Dihydrocoptisine can activate XBP1 transcription activity. Dihydrocoptisine can be studied in research on anti-ulcertative colitis.
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- CAS No.: 53777-78-9
- Formule: C19H15NO4
- Masse moléculaire:321.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI |
32.09 %
Compound: 2
|
Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition rate at 0.1 to 100 umol/L after 96 hrs by MTT assay
|
[PMID: 25203783] |
| A549 | IC50 |
>5 μg/mL
Compound: 2
|
Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition rate after 96 hrs by MTT assay
|
[PMID: 25203783] |
| Bel-7402 | IC50 |
>5 μg/mL
Compound: 2
|
Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay
Cytotoxicity against human Bel7402 cells assessed as growth inhibition rate after 96 hrs by MTT assay
|
[PMID: 25203783] |
| C-33-A | IC50 |
>5 μg/mL
Compound: 2
|
Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay
Cytotoxicity against human C33A cells assessed as growth inhibition rate after 96 hrs by MTT assay
|
[PMID: 25203783] |
| HCT-8 | IC50 |
>5 μg/mL
Compound: 2
|
Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay
Cytotoxicity against human HCT8 cells assessed as growth inhibition rate after 96 hrs by MTT assay
|
[PMID: 25203783] |
Chemical Information
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CAS No. 53777-78-9
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Masse moléculaire 321.33
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Formule C19H15NO4
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SMILES
O1C=2C=CC=3C=C4C5=CC=6OCOC6C=C5CCN4CC3C2OC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Singh S, et al., A new benzylisoquinoline alkaloid from Argemone mexicana. Nat Prod Res. 2010;24(1):63-7. [Content Brief]
[2]. Li X, et al., Trifluoromethylation of dihydrocoptisines and the effect on structural stability and XBP1-activating activity. J Asian Nat Prod Res. 2022 Apr;24(4):388-396. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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