Siglecg - sialic acid binding Ig-like lectin G Gene

Also Known as Siglec-G; Siglec10; mSiglec-G; 9830164H23; A630096C01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 243958

Summary

Predicted to enable SH2 domain binding activity; Phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of inflammatory response to wounding; and regulation of B cell proliferation. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in thymus primordium. Orthologous to several human genes including SIGLEC10 (sialic acid binding Ig like lectin 10). [provided by Alliance of Genome Resources, Apr 2022]

Siglecg Products (2)

mRNA Protein Name
NM_001382486.1 NP_001369415.1 sialic acid-binding Ig-like lectin 10 isoform 2 precursor
NM_172900.4 NP_766488.2 sialic acid-binding Ig-like lectin 10 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
19264983 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
involved in negative regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in negative regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in negative regulation of inflammatory response to wounding IPI
IPI: Inferred from physical interaction
19264983 MGI
involved in regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
20200274 MGI
involved in regulation of immune response IGI
IGI: Inferred from genetic interaction
20200274 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 10

  • sialic acid binding Ig-like lectin 10

  • siglec-10

Siglecg Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Siglec10 Q80ZE3 Rigi Mus musculus Q6Q899
Anti Tag CoIP
23374343
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Siglecg Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70448 Siglec-10 Protein, Mouse (HEK293, Fc) Q80ZE3 (M19-K543) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-185658 3'-BPANeuGc Inhibitor / Unkown
HY-RS26351 Siglec10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown