Faslg - Fas ligand Gene

Also Known as Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25385

Summary

Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic Cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]

Faslg Products (1)

mRNA	Protein	Name
NM_012908.1	NP_037040.1	tumor necrosis factor ligand superfamily member 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables death receptor binding	IPI IPI: Inferred from physical interaction	15557468	RGD
enables tumor necrosis factor receptor binding	IMP IMP: Inferred from mutant phenotype	16154149	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	10029626	RGD
involved in endosomal lumen acidification	IDA IDA: Inferred from direct assay	18045865	RGD
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	16689665	RGD
involved in inflammatory cell apoptotic process	IGI IGI: Inferred from genetic interaction	16154149	RGD
involved in intracellular chloride ion homeostasis	IDA IDA: Inferred from direct assay	18045865	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18471522	RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18471522	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9858598	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	18692025	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17899301	RGD

Cellular Component GO Annotation	Evidence	Références	Source
located in caveola	IDA IDA: Inferred from direct assay	15541714	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16563377	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor necrosis factor ligand superfamily member 6	Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand) CD95 ligand CD95L protein Fas antigen ligand Fas ligand (TNF superfamily, member 6) Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99445	Asunercept	Inhibitor	98.13%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-117738	Benarthin	Inhibitor	95.79%	Unkown
HY-RS04752	FASLG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174713	Human FASLG mRNA		/	Unkown
HY-RS24163	Faslg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Faslg	NCBI	NCBI:356
Mus musculus	Faslg	NCBI