1. Apoptosis
  2. TNF Receptor
  3. Asunercept

Asunercept  (Synonyms: APG101; CAN008)

Cat. No.: HY-P99445 Purity: 98.13%
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Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD).

For research use only. We do not sell to patients.

Asunercept Chemical Structure

Asunercept Chemical Structure

CAS No. : 1450882-18-4

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Description

Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3].

Species

Human

IC50 & Target

CD95L[1][2][3].

In Vitro

Asunercept (APG101; 0-100 µg/mL; preincubation for 30 min) specifically neutralizes the proapoptotic activity of recombinant CD95L in Jurkat A3 cells[1].
Asunercept (0.2, 2, 20 µg/mL; 72 h) is capable of interfering with CD95-induced migration/invasion of glioma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Jurkat A3 cells (APG293-induced)
Concentration: 0-100 µg/mL
Incubation Time: 30 min (preincubation)
Result: Completely neutralized APG293-induced apoptosis.

Cell Invasion Assay[1]

Cell Line: U87-MG cells (CD95L knockdown; APG293-induced)
Concentration: 0.2, 2, 20 µg/mL
Incubation Time: 72 h
Result: Blocked APG293 induced invasion of U87 cells (CD95L knockdown).
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Asunercept]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Asunercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Asunercept
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