1450882-18-4
1450882-18-4
Chemical Structure
Asunercept
Synonym(s): APG101; CAN008
- CAS No.: 1450882-18-4
- Formula:N/A
- Molecular Weight:(84.05 kDa)
IUPAC Name: 5-isopropyl-3-(piperidin-2-yl)-1,2,4-oxadiazole hydrochloride
SMILES: [Asunercept]
Biological Activity: Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein (hIgG1) targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3].
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Asunercept | 98.13% | Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein (hIgG1) targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD). | ||||||||||||||||||||
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References
- [1]. Merz C, et al. Neutralization of the CD95 ligand by APG101 inhibits invasion of glioma cells in vitro. Anticancer Drugs. 2015 Aug;26(7):716-27. [Content Brief]
- [2]. Krendyukov A, et al. Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies. Cancer Manag Res. 2019 Sep 2;11:8095-8100. [Content Brief]
- [3]. Radujkovic A, et al. Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile. Cancers (Basel). 2020 Dec 8;12(12):3683. [Content Brief]
