Rorb - RAR-related orphan receptor B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309288

About Rorb

Primary_assembly 1: 216,363,629-216,544,390 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 398 orthologues, 19 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 5.4), Uterus (RPKM 19.7) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

Rorb Products (2)

mRNA Protein Name
NM_001270958.1 NP_001257887.1 nuclear receptor ROR-beta
NM_001270958.1 NP_001257887.1 nuclear receptor ROR-beta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
7961794 RGD
enables melatonin receptor activity IDA
IDA: Inferred from direct assay
7961794 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to retinoic acid IDA
IDA: Inferred from direct assay
12958591 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
15781226 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9729429 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9729429 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17067745 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rorb Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (2 - 96)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (209 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-beta

  • RAR-related orphan receptor beta

  • nuclear receptor RZR-beta

  • nuclear receptor subfamily 1 group F member 2

  • retinoid-related orphan receptor-beta

  • transcription factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12129 RORB Human Pre-designed siRNA Set A / Unkown
HY-RS12130 Rorb Mouse Pre-designed siRNA Set A / Unkown
HY-RS12131 Rorb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rorb NCBI NCBI:6096