UPK3A - uroplakin 3A Gene

Also Known as UP3A; UPK3; UPIII; UPIIIA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7380

About UPK3A

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:45,284,949-45,295,874 (from NCBI)

This gene has 2 transcripts (splice variants), 116 orthologues, 3 paralogues and is associated with 1 phenotype. Biased expression in prostate (RPKM 9.1), urinary bladder (RPKM 5.3) and 4 other tissues.

Summary

This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

UPK3A Products (2)

mRNA	Protein	Name
NM_001167574.2	NP_001161046.1	uroplakin-3a isoform 2 precursor
NM_006953.4	NP_008884.1	uroplakin-3a isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	10514386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
uroplakin-3a	uroplakin 3

UPK3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	UPK3A	O75631	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	UPK3A	O75631	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	UPK3A	O75631	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	UPK3A	O75631	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	UPK3A	O75631	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

UPK3A Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81952	Uroplakin III Antibody (YA1697)	IHC-P, FC	Human
HY-P85930	Uroplakin III Antibody (YA5622)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Renal Hypodysplasia/Aplasia 3	RHDA3 Renal Agenesis, Unilateral Unilateral Renal Agenesis
Ovarian Brenner Tumor	Benign Ovarian Brenner Tumor Brenner Tumor Benign Ovarian Brenner Tumour Ovarian Brenner Tumour Brenner Tumor Of Ovary Benign Brenner Tumor
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Radiation Cystitis	Irradiation Cystitis
Urethra Transitional Cell Carcinoma	Urethral Transitional Cell Carcinoma Urethral Urothelial Carcinoma
Urethral Diverticulum	Urethral Sacculation
Renal Pelvis Transitional Cell Carcinoma	Urothelial Cell Carcinoma Of Renal Pelvis Renal Pelvis Urothelial Carcinoma Transitional Cell Carcinoma Of Renal Pelvis
Cystitis	Infective Cystitis Urocystitis Pyocystitis
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Urethral Syndrome	Urethral Disease Urethral Diseases Urethra Disease Abnormality Of The Urethra Urethral Disorders
Chronic Cystitis
Transitional Papilloma	Transitional Cell Papilloma Transitional Cell Papilloma, Benign
Vulval Paget'S Disease	Paget'S Disease Of Vulva Vulval Paget Disease Vulvar Paget'S Disease Extramammary Paget Disease Of Vulva
Vulva Adenocarcinoma	Adenocarcinoma Of The Vulva Adenocarcinoma Of Vulva
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Urethra Cancer	Cancer Of Urethra Malignant Tumour Of Urethra Malignant Urethral Neoplasm Urethral Ca
Acute Cystitis	Urinary Tract Infection Recurrent Urinary Tract Infection
Bladder Adenocarcinoma	Adenocarcinoma Of Bladder Adenocarcinoma Of The Urinary Bladder Bladder Adenocarcinoma, Not Otherwise Specified Adenocarcinoma Bladder
Glandular Cystitis	Cystitis Glandularis
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex	Exstrophy-Epispadias Complex Bladder Exstrophy-Epispadias-Cloacal Extrophy Complex Beec Eec Exstrophy Of The Bladder Bladder Exstrophy Bladder Exstrophy And Epispadias Complex
Nephrogenic Adenoma	Nephrogenic Metaplasia
Congenital Anomalies Of Kidney And Urinary Tract 2	CAKUT2 Ureteropelvic Junction Obstruction Multicystic Renal Dysplasia, Bilateral Pelviureteric Junction Obstruction Pujo Hydronephrosis Due To Pujo Upjo Mcrd Congenital Anomalies Of The Kidney And Urinary Tract 2 Mrd Pelvi-Ureteric Junction Obstruction Kidney And Urinary Tract, Anomalies, Congenital, Type 2 Obstruction Of Pelviureteric Junction
Bladder Papillary Transitional Cell Neoplasm	Urinary Bladder Papillary Urothelial Neoplasm Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm	Inverted Papilloma Of Urinary Tract Papillary Transitional Cell Neoplasm Of The Urinary Tract Urinary Tract Inverted Papilloma Inverted Urothelial Papilloma
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma
Bladder Transitional Cell Papilloma	Bladder Papilloma Transitional Cell Papilloma Of Bladder Urinary Bladder Urothelial Papilloma Urothelial Papilloma Bladder Urothelial Papilloma
Gastric Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Stomach Squamous Cell Carcinoma Of The Stomach
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Ureteral Benign Neoplasm	Neoplasm Of Ureter Ureteral Tumor Cancer Of The Ureter Malignant Tumour Of Ureter Ureteric Cancer Primary Malignant Neoplasm Of Ureter
Papillorenal Syndrome	Renal Coloboma Syndrome Coloboma Of Optic Nerve With Renal Disease Renal-Coloboma Syndrome Optic Nerve Coloboma With Renal Disease Optic Coloboma, Vesicoureteral Reflux, And Renal Anomalies Renal-Coloboma Syndrome With Macular Abnormalities Congenital Anomalies Of The Kidney And Urinary Tract With Or Without Ocular Abnormalities Cakut With Or Without Ocular Abnormalities PAPRS Optic Coloboma, Vesicoureteral Reflux And Renal Anomalies Papillo-Renal Syndrome, Optic Nerve Coloboma With Renal Disease Coloboma-Ureteral-Renal Syndrome Oncr Optic Nerve Coloboma Renal Syndrome Rcs Papillo-Renal Syndrome Optic Coloboma Vesicoureteral Reflux And Renal Anomalies
Bladder Clear Cell Adenocarcinoma	Bladder Mesonephric Adenocarcinoma Clear Cell Adenocarcinoma Of Bladder
Urethral Stricture	Ankylurethria Urethral Stenosis Urethral Contracture Urethral Obstruction Meatal Stenosis Nos Constriction Of Urethra Contraction Of Urethra Stricture Of Urinary Meatus Urethral Obliteration Urethral Narrowing Pinpoint Meatus Pinhole Meatus Nos Urethral Occlusion
Non-Invasive Bladder Papillary Urothelial Neoplasm	Bladder Papillary Neoplasm Of Low Malignant Potential Bladder Punlmp Papillary Urothelial Neoplasm Of Low Malignant Potential Papillary Transitional Cell Neoplasm Of Low Malignant Potential
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Pyuria	Pus Cells In Urine
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Bladder Exstrophy	Exstrophy Of The Bladder Classic Exstrophy Of The Bladder
Papillary Transitional Carcinoma	Papillary Transitional Cell Carcinoma
Cranioectodermal Dysplasia 1	Sensenbrenner Syndrome CED1 Levin Syndrome I Cranio-Ectodermal Dysplasia Dysplasia, Cranioectodermal, Type 1 Cranioectodermal Dysplasia
Hemorrhagic Cystitis
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15488	UPK3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UPK3A	VGNC	VGNC:48157
Felis catus	UPK3A	VGNC	VGNC:66845
Rattus norvegicus	UPK3A	RGD	RGD:1310633
Macaca mulatta	UPK3A	VGNC	VGNC:78728
Mus musculus	UPK3A	MGD	MGI:98914
Bos taurus	UPK3A	VGNC	VGNC:36687
Others	UPK3A	NCBI