Cbl-b-IN-32
Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263.
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- Formel: C16H17F3N2O
- Molecular Weight:310.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Biologische Aktivität
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Cbl-b 6.83 μM (IC50) |
Cbl-b-IN-32 (compound 27) (2-50 μM) directly binds to purified His-Cbl-b protein, inducing a concentration-dependent decrease in protein thermal stability with a ΔTm of -7.0 °C at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 310.31
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Formel C16H17F3N2O
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SMILES
O=C1C(C2=CC=CC(C(CCN)C)=C2)=CC(C(F)(F)F)=CN1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cbl-b-IN-32 Related Classifications
HY-183293 Related Classifications
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