Cergutuzumab
Based on 1 Customer Validation
Cergutuzumab is a fully human IgG1 antibody that targets carcinoembryonic antigen (CEA, CEACAM5, CD66e). Cergutuzumab can be used to form the recombinant protein Cergutuzumab amunaleukin (HY-P99498).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.86%
- CAS. Nr.: 1622305-37-6
- Molecular Weight:145.595 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Human IgG1 (L234A/L235A) kappa
Human
CEACAM5/CEA/CD66e
Cergutuzumab amunaleukin exhibits potential immunostimulatory and antineoplastic activities. Upon administration, the Cergutuzumab moiety recognizes and binds to CEA, thereby specifically targeting IL-2v to CEA-expressing tumor tissues[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Immobilized CEACAM5 Protein, Human (HEK293, His, HY-P70675) can bind Cergutuzumab. The EC50 for this effect is 4.392 ng/mL. -
Flow cytometric analysis of 1×106 MCF-7 cells with Cergutuzumab (HY-P991060, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
Chemical Information
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CAS. Nr. 1622305-37-6
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Appearance Liquid
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Molecular Weight 145.595 kDa
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Color Colorless to light yellow
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SMILES
[Cergutuzumab]
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
[1]. Flisikowska T, et al. A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies. Nat Biomed Eng. 2022;6(11):1248-1256. [Content Brief]
[2]. Klein C, et al. Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines. Oncoimmunology. 2017;6(3):e1277306. Published 2017 Jan 11. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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