Dasiglucagon acetate
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Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.66%
- Formel: C154H226N38O52
- Molecular Weight:3441.67
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Speicherung:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biologische Aktivität
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In Vivo
Dasiglucagon PK profile shows a dose-dependent and rapid increase in plasma levels[2].
| Dasiglucagon dose | ||||
| 0.1 mg | 0.3 mg | 0.6 mg | 1.0 mg | |
| N | 5 | 16 | 16 | 16 |
| AUC0–30min (pmol*h/L) | 99.4 (32.0) | 302 (78.9) | 444 (163) | 884 (307) |
| AUC0–360min (pmol*h/L) | 451 (123) | 1360 (166) | 1630 (368) | 4800 (697) |
| AUC0–inf (pmol*h/L) | 451 (123) | 1360 (166) | 2640 (365) | 4810 (696) |
| Cmax (pmol/L) | 334 (113) | 976 (208) | 1570 (445) | 2800 (767) |
| tmax (h) | 0.50 (0.5-0.6) | 0.63 (0.3-0.8) | 0.58 (0.5-1.7) | 0.63 (0.3-0.8) |
| t1/2 (h) | 0.43 (0.07) | 0.43 (0.07) | 0.49 (0.14) | 0.54 (0.17) |