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Prkaa1 - protein kinase, AMP-activated, alpha 1 catalytic subunit Gene

Also Known as AMPKalpha1; C130083N04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 105787

Summary

Enables AMP-activated protein kinase activity; chromatin binding activity; and histone serine kinase activity. Involved in several processes, including regulation of gene expression; regulation of organelle organization; and regulation of protein modification process. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; positive regulation of skeletal muscle tissue development; and regulation of peptidyl-serine phosphorylation. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in several structures, including brain; early conceptus; future brain; and spinal cord. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa1 Products (2)

mRNA	Protein	Name
NM_001013367.3	NP_001013385.3	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
NM_001355640.1	NP_001342569.1	5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	15878856	MGI
enables AMP-activated protein kinase activity	IGI IGI: Inferred from genetic interaction	25788287	MGI
enables AMP-activated protein kinase activity	IMP IMP: Inferred from mutant phenotype	16308421	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20647423	MGI
enables histone H2BS36 kinase activity	IDA IDA: Inferred from direct assay	20647423	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15878856	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	32912901	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IGI IGI: Inferred from genetic interaction	25788287	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21258367	MGI
involved in cellular response to glucose stimulus	IGI IGI: Inferred from genetic interaction	25788287	MGI
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	21258367	MGI
involved in cellular response to oxidative stress	IGI IGI: Inferred from genetic interaction	27430620	MGI
acts upstream of or within cellular response to prostaglandin E stimulus	IGI IGI: Inferred from genetic interaction	23479225	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	36977414	MGI
acts upstream of or within fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	12802337	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	16308421	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12802337	MGI
involved in lipid biosynthetic process	IDA IDA: Inferred from direct assay	21459323	MGI
involved in negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18439900	MGI
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	32912901	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18439900	MGI
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	15878856	MGI
involved in negative regulation of tubulin deacetylation	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20647423	MGI
involved in positive regulation of adipose tissue development	IDA IDA: Inferred from direct assay	32822587	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	21258367	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23926128	MGI
involved in positive regulation of mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	23283301	MGI
involved in positive regulation of peptidyl-lysine acetylation	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in positive regulation of protein localization	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in positive regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	23283301	MGI
acts upstream of or within positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	23926128	MGI
involved in protein localization to lipid droplet	IDA IDA: Inferred from direct assay	34077757	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	19833968	MGI
involved in regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	27430620	MGI
acts upstream of or within regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23926128	MGI
involved in regulation of stress granule assembly	IGI IGI: Inferred from genetic interaction	27430620	MGI
involved in response to UV	IMP IMP: Inferred from mutant phenotype	20647423	MGI
involved in response to gamma radiation	IMP IMP: Inferred from mutant phenotype	20647423	MGI
involved in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	20647423	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IGI IGI: Inferred from genetic interaction	25788287	MGI
is active in chromatin	IDA IDA: Inferred from direct assay	32822587	MGI
located in chromatin	IDA IDA: Inferred from direct assay	32822587	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	18381428	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18381428	MGI
located in dendrite	IGI IGI: Inferred from genetic interaction	25788287	MGI
located in neuronal cell body	IGI IGI: Inferred from genetic interaction	25788287	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19833968	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5'-AMP-activated protein kinase catalytic subunit alpha-1	ACACA kinase AMP-activated protein kinase, alpha 1 catalytic subunit AMPK subunit alpha-1 HMGCR kinase acetyl-CoA carboxylase kinase hydroxymethylglutaryl-CoA reductase kinase tau-protein kinase PRKAA1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-RS11100	PRKAA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11779	Ac-RKAA-PABC-MMAE	Inhibitor	/	Unkown
HY-P11779A	Ac-RKAA-PABC-MMAE TFA	Inhibitor	/	Unkown
HY-RS29496	Prkaa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185634	PROTAC GSK3 degrader-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaa1	NCBI	NCBI:5562