RAB32 - RAB32, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10981

About RAB32

Cytogenetic location: 6q24.3 Genomic coordinates (GRCh38): 6:146,543,833-146,554,953 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues and 68 paralogues. Broad expression in bone marrow (RPKM 49.7), spleen (RPKM 19.8) and 23 other tissues.

Summary

The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in Autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]

RAB32 Products (1)

mRNA Protein Name
NM_006834.5 NP_006825.1 ras-related protein Rab-32

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables AP-1 adaptor complex binding IPI
IPI: Inferred from physical interaction
22511774 GOA
NOT enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
22511774 GOA
enables AP-3 adaptor complex binding IPI
IPI: Inferred from physical interaction
22511774 GOA
enables BLOC-2 complex binding IPI
IPI: Inferred from physical interaction
22511774 GOA
enables GTP-dependent protein binding IPI
IPI: Inferred from physical interaction
22511774 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
21808068 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21808068 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
19717423 GOA
involved in endosome to melanosome transport IMP
IMP: Inferred from mutant phenotype
22511774 GOA
involved in melanosome assembly IDA
IDA: Inferred from direct assay
23084991 GOA
involved in melanosome assembly IMP
IMP: Inferred from mutant phenotype
22511774 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
25767741 GOA
involved in phagosome maturation IMP
IMP: Inferred from mutant phenotype
21255211 GOA
involved in protein localization to membrane IMP
IMP: Inferred from mutant phenotype
25767741 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in early endosome IDA
IDA: Inferred from direct assay
22511774 GOA
NOT located in early endosome lumen IDA
IDA: Inferred from direct assay
22511774 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25767741 GOA
located in melanosome IDA
IDA: Inferred from direct assay
22511774 GOA
located in melanosome membrane IDA
IDA: Inferred from direct assay
23084991 GOA
located in membrane IDA
IDA: Inferred from direct assay
22511774 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
25767741 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
23084991 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25767741 GOA
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB32 Protein Structure

Ras

Ras: Ras family (27 - 192)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-32

RAB32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAB32 Q13637 LRMDA Homo sapiens A0A087WWI0
Y2H Prey Pooling
32296183
Intra
RAB32 Q13637 LRMDA Homo sapiens A0A087WWI0
Y2H Array
32296183
Intra
RAB32 Q13637 LRRK2 Homo sapiens Q5S007
Anti Bait CoIP
25360523
Intra
RAB32 Q13637 LRRK2 Homo sapiens Q5S007
FPS
31552791
Intra
RAB32 Q13637 LRRK2 Homo sapiens Q5S007
Pull Down
31552791
Intra
RAB32 Q13637 LRRK2 Homo sapiens Q5S007
Y2H
25360523
Intra
RAB32 Q13637 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
RAB32 Q13637 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
RAB32 Q13637 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB32 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P89800 Rab 32 Antibody (YA9144) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Leprosy 3

  • Leprosy

  • Leprosy, Susceptibility To, 3

  • Hansen'S Disease

  • Leprosy, Susceptibility To

  • Hansen Disease

  • Infection Due To Mycobacterium Leprae

  • LPRS3

  • Leprosy, Type 3

  • Anaesthesia Leprosy

  • Anaesthetic Leprosy

  • Maculoanaesthetic Leprosy

  • Macular Leprosy

  • Leprosy Unspecified
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Warburg Micro Syndrome 1

  • Warburg Micro Syndrome

  • Micro Syndrome

  • Warbm

  • WARBM1

  • Warburg Sjo Fledelius Syndrome

  • Warburg-Sjo-Fledelius Syndrome

  • Micro Syndrome 1

  • Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

  • Charcot-Marie-Tooth Disease Type 4

  • Charcot-Marie-Tooth Disease Type 4e

  • Hereditary Motor And Sensory Neuropathy

  • Cmt4e

  • CHN1

  • Hypomyelinating Neuropathy, Congenital, 1

  • Charcot-Marie-Tooth Neuropathy Type 4e

  • Neuropathy, Congenital Hypomyelinating, 1

  • Ar-Cmt1

  • Autosomal Recessive Demyelinating Charcot-Marie-Tooth

  • Cmt4

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

  • Hypomyelination, Severe Congenital

  • Charcot-Marie-Tooth Disease, Type 4e

  • Charcot-Marie-Tooth Neuropathy, Type 4e

  • Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

  • Autosomal Recessive Congenital Hypomyelinating Neuropathy

  • Congenital Amyelinating Neuropathy

  • Congenital Hypomyelinating Neuropathy Autosomal Recessive

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating

  • Severe Congenital Hypomyelination

  • Hereditary Sensory Motor Neuropathy

  • Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

  • Neuropathy, Hypomyelinating, Congenital, Type 1

  • Neuropathy, Motor And Sensory, Hereditary

  • Congenital Hypomyelinating Neuropathy

  • Hereditary Motor And Sensory Neuropathies

  • Hereditary Sensorimotor Neuropathy

  • Hmsn - [Hereditary Motor And Sensory Neuropathy]

  • Hsmn - [Hereditary Sensory And Motor Neuropathy]

  • Hereditary Motor And Sensory Neuropathy, Types I-Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11545 RAB32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21712 Rab32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28230 Rab32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB32 MGD MGI:1915094
Rattus norvegicus RAB32 RGD RGD:1559997
Canis familiaris RAB32 VGNC VGNC:53757
Bos taurus RAB32 VGNC VGNC:33641
Others RAB32 NCBI