NINL - ninein like Gene

Also Known as NLP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22981

About NINL

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,452,697-25,585,531 (from NCBI)

This gene has 7 transcripts (splice variants), 176 orthologues and 1 paralogue. Broad expression in kidney (RPKM 4.4), ovary (RPKM 3.4) and 23 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Located in cytosol; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

NINL Products (2)

mRNA Protein Name
NM_001318226.2 NP_001305155.1 ninein-like protein isoform 2
NM_025176.6 NP_079452.3 ninein-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in centrosome IDA
IDA: Inferred from direct assay
26485514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NINL Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (226 - 259)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1382 a.a.
Protein Preferred Names Protein Names

ninein-like protein

NINL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NINL Q9Y2I6 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra
NINL Q9Y2I6 CCDC146 Homo sapiens Q8IYE0-2
Y2H Array
25416956
Intra
NINL Q9Y2I6 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra
NINL Q9Y2I6 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
25416956
Intra
NINL Q9Y2I6 KAT5 Homo sapiens Q92993
Y2H Array
25416956
Intra
NINL Q9Y2I6 FAM161A Homo sapiens Q3B820
Validated Y2H
25416956
Intra
NINL Q9Y2I6 RBM41 Homo sapiens Q96IZ5
Validated Y2H
25416956
Intra
NINL Q9Y2I6 RBM41 Homo sapiens Q96IZ5
Y2H Array
25416956
Intra
NINL Q9Y2I6 RCOR3 Homo sapiens Q9P2K3
Validated Y2H
25416956
Intra
NINL Q9Y2I6 RCOR3 Homo sapiens Q9P2K3
Y2H Pooling
16189514
Intra
NINL Q9Y2I6 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
NINL Q9Y2I6 L3MBTL4 Homo sapiens Q8NA19
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichostrongylosis

  • Trichostrongyliasis

  • Infection By Trichostrongylus

  • Infection By Trichostrongylus Species

  • Trichostrongylus Infestation
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance

  • Hodgkin Disease

  • Hodgkin Lymphoma, Lymphocyte-Rich

  • Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance

  • Hodgkin'S Disease, Lymphocyte Predominance

  • Lymphocyte Rich Hodgkin'S Disease

  • Lymphocyte Rich Classical Hodgkin Lymphoma
Trichostrongyloidiasis
Hypotrichosis 1

  • HYPT1

  • Hhs

  • Hts

  • Hypotrichosis Simplex

  • Hypotrichosis Simplex, Generalized, Hereditary

  • Hereditary Generalized Hypotrichosis Simplex

  • Generalized Hypothricosis Simplex

  • Hypotrichosis Simplex Hereditary

  • Hypotrichosis, Type 1
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09300 NINL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NINL MGD MGI:1925427
Macaca mulatta NINL VGNC VGNC:75273
Felis catus NINL VGNC VGNC:63805
Canis familiaris NINL VGNC VGNC:43813
Rattus norvegicus NINL RGD RGD:1306152
Others NINL NCBI