LPIN1 - lipin 1 Gene

Also Known as PAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23175

About LPIN1

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,677,544-11,827,409 (from NCBI)

This gene has 20 transcripts (splice variants), 273 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 18.7), ovary (RPKM 8.2) and 24 other tissues.

Summary

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of Other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

LPIN1 Products (13)

mRNA Protein Name
NM_001261427.3 NP_001248356.1 phosphatidate phosphatase LPIN1 isoform 2
NM_001261428.3 NP_001248357.1 phosphatidate phosphatase LPIN1 isoform 3
NM_001349199.2 NP_001336128.1 phosphatidate phosphatase LPIN1 isoform 1
NM_001349200.2 NP_001336129.1 phosphatidate phosphatase LPIN1 isoform 5
NM_001349201.2 NP_001336130.1 phosphatidate phosphatase LPIN1 isoform 5
NM_001349202.2 NP_001336131.1 phosphatidate phosphatase LPIN1 isoform 6
NM_001349203.2 NP_001336132.1 phosphatidate phosphatase LPIN1 isoform 6
NM_001349204.2 NP_001336133.1 phosphatidate phosphatase LPIN1 isoform 7
NM_001349205.2 NP_001336134.1 phosphatidate phosphatase LPIN1 isoform 7
NM_001349206.2 NP_001336135.1 phosphatidate phosphatase LPIN1 isoform 7
NM_001349207.2 NP_001336136.1 phosphatidate phosphatase LPIN1 isoform 8
NM_001349208.2 NP_001336137.1 phosphatidate phosphatase LPIN1 isoform 9
NM_145693.4 NP_663731.1 phosphatidate phosphatase LPIN1 isoform 1

LPIN1 Protein Structure

Lipin_N

Lipin_N: lipin, N-terminal conserved region (1 - 111)

LNS2

LNS2: LNS2 (Lipin/Ned1/Smp2) (674 - 830)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
Protein Preferred Names Protein Names

phosphatidate phosphatase LPIN1

LPIN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
LPIN1 Q14693 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra
LPIN1 Q14693 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra
LPIN1 Q14693 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra
LPIN1 Q14693 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
LPIN1 Q14693 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
LPIN1 Q14693 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
LPIN1 Q14693 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
LPIN1 Q14693 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
LPIN1 Q14693 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
LPIN1 Q14693 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra
LPIN1 Q14693 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra
LPIN1 Q14693 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra
LPIN1 Q14693 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
LPIN1 Q14693 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
LPIN1 Q14693 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
LPIN1 Q14693 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
LPIN1 Q14693 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
LPIN1 Q14693 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
LPIN1 Q14693 DBH Homo sapiens P09172
Y2H Pooling
32814053
Intra
LPIN1 Q14693 DBH Homo sapiens P09172
Validated Y2H
32814053
Intra
LPIN1 Q14693 DBH Homo sapiens P09172
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

LPIN1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82164 Lipin 1 Antibody (YA1909) WB, IHC-P, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
Myoglobinuria, Acute Recurrent, Autosomal Recessive

  • Myoglobinuria, Familial Paroxysmal Paralytic

  • Rhabdomyolysis, Acute Recurrent

  • ARARM

  • Acute Recurrent Rhabdomyolysis

  • Familial Paroxysmal Paralytic Myoglobinuria
Genetic Recurrent Myoglobinuria
Myoglobinuria
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Peroneal Neuropathy

  • Peroneal Neuropathies
Febrile Seizures, Familial, 5

  • FEB5

  • Familial Febrile Seizures 5

  • Convulsions, Familial Febrile, 5

  • Familial Febrile Convulsions 5

  • Febrile Convulsions, Familial, 5
Lipodystrophy, Congenital Generalized, Type 1

  • Congenital Generalized Lipodystrophy Type 1

  • Bscl1

  • CGL1

  • Berardinelli-Seip Congenital Lipodystrophy, Type 1

  • Brunzell Syndrome Agpat2-Related

  • Berardinelli-Seip Congenital Lipodystrophy Type 1

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 1

  • Brunzell Syndrome, Agpat2-Related

  • Agpat2-Related Brunzell Syndrome

  • Congenital Generalized Lipodystrophy 1

  • Berardinelli-Seip Syndrome

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Lipodystrophy, Generalized, Congenital, Type 1

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Inflammatory Bowel Disease 27

  • IBD27
Complete Generalized Lipodystrophy
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Chanarin-Dorfman Syndrome

  • Neutral Lipid Storage Disease

  • CDS

  • Neutral Lipid Storage Disease With Ichthyosis

  • Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

  • Triglyceride Storage Disease With Ichthyosis

  • Nlsdi

  • Ichthyotic Neutral Lipid Storage Disease

  • Dorfman-Chanarin Syndrome

  • Dcs

  • Chanarin-Dorfman Disease

  • Ichthyosiform Erythroderma With Leukocyte Vacuolation

  • Lipidosis With Triglyceride Storage Disease

  • Disorder Of Cornification 12

  • Dorfman Chanarin Syndrome

  • Neutral Lipid Storage Disease With Ichthyotic

  • Dorfman-Chanarin Disease
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS19455 Lpin1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07769 LPIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25948 Lpin1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LPIN1 VGNC VGNC:42751
Rattus norvegicus LPIN1 RGD RGD:1307646
Macaca mulatta LPIN1 VGNC VGNC:74278
Felis catus LPIN1 VGNC VGNC:63268
Mus musculus LPIN1 MGD MGI:1891340
Bos taurus LPIN1 VGNC VGNC:30966
Others LPIN1 NCBI