GRIP1 - glutamate receptor interacting protein 1 Gene

Also Known as GRIP; FRASRS3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23426

About GRIP1

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:66,347,431-67,069,338 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues.

Summary

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GRIP1 Products (11)

mRNA Protein Name
NM_001178074.2 NP_001171545.1 glutamate receptor-interacting protein 1 isoform 2
NM_001366722.1 NP_001353651.1 glutamate receptor-interacting protein 1 isoform 3
NM_001366723.1 NP_001353652.1 glutamate receptor-interacting protein 1 isoform 4
NM_001366724.1 NP_001353653.1 glutamate receptor-interacting protein 1 isoform 5
NM_001379345.1 NP_001366274.1 glutamate receptor-interacting protein 1 isoform 6
NM_001379346.1 NP_001366275.1 glutamate receptor-interacting protein 1 isoform 7
NM_001379347.1 NP_001366276.1 glutamate receptor-interacting protein 1 isoform 8
NM_001379348.1 NP_001366277.1 glutamate receptor-interacting protein 1 isoform 9
NM_001379349.1 NP_001366278.1 glutamate receptor-interacting protein 1 isoform 10
NM_001379351.1 NP_001366280.1 glutamate receptor-interacting protein 1 isoform 11
NM_021150.4 NP_066973.2 glutamate receptor-interacting protein 1 isoform 1
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11641419 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIP1 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (54 - 133)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (152 - 235)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (259 - 333)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (477 - 558)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (575 - 655)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (674 - 751)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1006 - 1082)

  • 0
  • 200
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  • 800
  • 1000
  • 1128 a.a.
Protein Preferred Names Protein Names

glutamate receptor-interacting protein 1

GRIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GRIP1 Q9Y3R0 IRF3 Homo sapiens Q14653 16362036
Intra
GRIP1 Q9Y3R0 YWHAE Homo sapiens P62258 36931259
Intra
GRIP1 Q9Y3R0 PSMB9 Homo sapiens P28065
Y2H
16957778
Intra
GRIP1 Q9Y3R0 PSMB9 Homo sapiens P28065 16957778
Intra
GRIP1 Q9Y3R0 ESR1 Homo sapiens P03372 17545996
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fraser Syndrome 3
  • FRASRS3

Fraser Syndrome 1
  • Fraser Syndrome

  • Cryptophthalmos With Other Malformations

  • Cryptophthalmos Syndrome

  • FRASRS1

  • Cryptophthalmos-Syndactyly Syndrome

  • Fraser-Francois Syndrome

  • Cyclopism

  • Meyer-Schwickerath'S Syndrome

  • Ulrich-Feichtiger Syndrome

  • Cryptophthalmos Syndactyly Syndrome

  • Fraser'S Syndrome

  • Meyer-Schwickerath Syndrome

  • Ullrich-Feichtiger Syndrome

Cryptophthalmos
Renal Hypodysplasia/Aplasia 1
  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney

Retinitis Pigmentosa 55
  • RP55

  • Retinitis Pigmentosa, Type 55

Chromosome 2q35 Duplication Syndrome
  • Syndactyly

  • Syndactyly Type 1

  • Sdty1

  • Zygodactyly

  • Syndactyly, Type I

  • Sd1

  • Syndactyly, Type 1, With Or Without Craniosynostosis

  • Symphalangism

  • Non-Syndromic Syndactyly

  • Symphalangy

  • Webbing Of Digits

  • Syndactyly, Type 1

Fragile X Syndrome
  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • X-Linked Intellectual Disability And Macroorchidism

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome

Cri-Du-Chat Syndrome
  • 5p Deletion Syndrome

  • 5p Partial Monosomy Syndrome

  • Monosomy 5p

  • Cat Cry Syndrome

  • Chromosome 5p Deletion Syndrome

  • Cri Du Chat Syndrome

  • 5p- Syndrome

  • 5p Minus Syndrome

  • Chromosome 5p- Syndrome

  • Chromosome 5 Short Arm Deletion Syndrome

  • Chromosome 5p Deletion

  • Deletion 5p

  • Cri Du Chat

  • 5p Partial Deletion Syndrome

  • Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus GRIP1 MGD MGI:1921303
Bos taurus GRIP1 VGNC VGNC:56205
Felis catus GRIP1 VGNC VGNC:62714
Rattus norvegicus GRIP1 RGD RGD:621667
Macaca mulatta GRIP1 VGNC VGNC:73195
Canis familiaris GRIP1 VGNC VGNC:41498
Others GRIP1 NCBI