GRIP1 - glutamate receptor interacting protein 1 Gene
Also Known as GRIP; FRASRS3
Species: Homo sapiens
About GRIP1
This gene has 20 transcripts (splice variants), 207 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 1.6), skin (RPKM 1.5) and 23 other tissues.
Summary
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
GRIP1 Products (11)
| mRNA | Protein | Name |
|---|---|---|
| NM_001178074.2 | NP_001171545.1 | glutamate receptor-interacting protein 1 isoform 2 |
| NM_001366722.1 | NP_001353651.1 | glutamate receptor-interacting protein 1 isoform 3 |
| NM_001366723.1 | NP_001353652.1 | glutamate receptor-interacting protein 1 isoform 4 |
| NM_001366724.1 | NP_001353653.1 | glutamate receptor-interacting protein 1 isoform 5 |
| NM_001379345.1 | NP_001366274.1 | glutamate receptor-interacting protein 1 isoform 6 |
| NM_001379346.1 | NP_001366275.1 | glutamate receptor-interacting protein 1 isoform 7 |
| NM_001379347.1 | NP_001366276.1 | glutamate receptor-interacting protein 1 isoform 8 |
| NM_001379348.1 | NP_001366277.1 | glutamate receptor-interacting protein 1 isoform 9 |
| NM_001379349.1 | NP_001366278.1 | glutamate receptor-interacting protein 1 isoform 10 |
| NM_001379351.1 | NP_001366280.1 | glutamate receptor-interacting protein 1 isoform 11 |
| NM_021150.4 | NP_066973.2 | glutamate receptor-interacting protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11641419 | GOA |
GRIP1 Protein Structure
PDZ: PDZ domain (Also known as DHR or GLGF) (54 - 133)
PDZ: PDZ domain (Also known as DHR or GLGF) (152 - 235)
PDZ: PDZ domain (Also known as DHR or GLGF) (259 - 333)
PDZ: PDZ domain (Also known as DHR or GLGF) (477 - 558)
PDZ: PDZ domain (Also known as DHR or GLGF) (575 - 655)
PDZ: PDZ domain (Also known as DHR or GLGF) (674 - 751)
PDZ: PDZ domain (Also known as DHR or GLGF) (1006 - 1082)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1128 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glutamate receptor-interacting protein 1 |
|
GRIP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
GRIP1 | Q9Y3R0 | IRF3 | Homo sapiens | Q14653 | 16362036 | |
|
Intra
|
GRIP1 | Q9Y3R0 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
GRIP1 | Q9Y3R0 | PSMB9 | Homo sapiens | P28065 | 16957778 | |
|
Intra
|
GRIP1 | Q9Y3R0 | PSMB9 | Homo sapiens | P28065 | 16957778 | |
|
Intra
|
GRIP1 | Q9Y3R0 | ESR1 | Homo sapiens | P03372 | 17545996 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Fraser Syndrome 3 |
|
|
| Fraser Syndrome 1 |
|
|
| Cryptophthalmos |
|
|
| Renal Hypodysplasia/Aplasia 1 |
|
|
| Retinitis Pigmentosa 55 |
|
|
| Chromosome 2q35 Duplication Syndrome |
|
|
| Fragile X Syndrome |
|
|
| Cri-Du-Chat Syndrome |
|
|
| Schizophrenia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | GRIP1 | MGD | MGI:1921303 |
| Bos taurus | GRIP1 | VGNC | VGNC:56205 |
| Felis catus | GRIP1 | VGNC | VGNC:62714 |
| Rattus norvegicus | GRIP1 | RGD | RGD:621667 |
| Macaca mulatta | GRIP1 | VGNC | VGNC:73195 |
| Canis familiaris | GRIP1 | VGNC | VGNC:41498 |
| Others | GRIP1 | NCBI |