Pmch - pro-melanin-concentrating hormone Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24659

Summary

Enables type 1 melanin-concentrating hormone receptor binding activity. Involved in several processes, including lactation; modulation of chemical synaptic transmission; and positive regulation of circadian sleep/wake cycle, REM sleep. Located in extracellular space. Biomarker of obesity. Orthologous to human PMCH (pro-melanin concentrating hormone). [provided by Alliance of Genome Resources, Apr 2022]

Pmch Products (1)

mRNA Protein Name
NM_012625.2 NP_036757.2 pro-MCH precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables type 1 melanin-concentrating hormone receptor binding IDA
IDA: Inferred from direct assay
10421367 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in drinking behavior IDA
IDA: Inferred from direct assay
17188345 RGD
involved in feeding behavior IDA
IDA: Inferred from direct assay
12355323 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
14962080 RGD
involved in negative regulation of blood pressure IDA
IDA: Inferred from direct assay
17045349 RGD
involved in negative regulation of synaptic transmission, dopaminergic IDA
IDA: Inferred from direct assay
15555641 RGD
involved in positive regulation of circadian sleep/wake cycle, REM sleep IDA
IDA: Inferred from direct assay
12964948 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
10559938 RGD
involved in regulation of heart rate IDA
IDA: Inferred from direct assay
17045349 RGD
involved in regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11814630 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
11483240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-MCH

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10759 PMCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22282 Pmch Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28805 Pmch Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pmch NCBI NCBI:5367