OOEP - oocyte expressed protein Gene

Also Known as KHDC2; FLOPED; HOEP19; C6orf156

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 441161

About OOEP

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,368,555-73,369,897 (from NCBI)

This gene has 3 transcripts (splice variants), 98 orthologues and 1 paralogue. Biased expression in testis (RPKM 5.4), placenta (RPKM 0.5) and 1 other tissue.

Summary

Predicted to enable RNA binding activity. Predicted to be involved in several processes, including Cytoskeleton organization; positive regulation of double-strand break repair via homologous recombination; and positive regulation of meiotic nuclear division. Predicted to act upstream of or within several processes, including embryo implantation; in utero embryonic development; and protein phosphorylation. Located in cytoplasm and nucleus. Part of subcortical maternal complex. [provided by Alliance of Genome Resources, Apr 2022]

OOEP Products (1)

mRNA	Protein	Name
NM_001080507.3	NP_001073976.1	oocyte-expressed protein homolog

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25542835	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25542835	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25542835	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	26537248	GOA
part of subcortical maternal complex	IDA IDA: Inferred from direct assay	25542835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
oocyte-expressed protein homolog	KH homology domain containing 2

OOEP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	OOEP	A6NGQ2	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	KHDC3L	Homo sapiens	Q587J8	Anti Tag CoIP	25542835
Intra	OOEP	A6NGQ2	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	TLE6	Homo sapiens	Q9H808-1	Anti Tag CoIP	25542835
Intra	OOEP	A6NGQ2	SNRPB	Homo sapiens	P14678-2	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	ALOX5	Homo sapiens	P09917	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	OOEP	A6NGQ2	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gestational Trophoblastic Neoplasm	Hydatidiform Mole Molar Pregnancy Gestational Trophoblastic Neoplasia Gestational Trophoblastic Tumor Gtn Gestational Trophoblastic Disease Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole Benign Trophoblastic Disease Trophoblastic Disease Nos Trophoblastic Disorder Vesicular Mole Nos Vesicular Mole Hydatidiform Mole Nos
Trophoblastic Neoplasm	Trophoblastic Tumor Trophoblastic Neoplasms
Temple Syndrome	Uniparental Disomy, Maternal, Chromosome 14 Temple Syndrome Due To Paternal 14q32.2 Microdeletion Paternal Del(14)(Q32.2) Temple Syndrome Due To Paternal 14q32.2 Hypomethylation Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14 Upd(14)Mat
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Transient Neonatal Diabetes Mellitus	Diabetes Mellitus, Transient Neonatal Tndm Chromosome 6-Associated Transient Diabetes Mellitus Dmtn Diabetes Mellitus, 6q24-Related Transient Neonatal Tndm1 Neonatal Diabetes Mellitus, Transient Tndm -[Transient Neonatal Diabetes Mellitus]
Kagami-Ogata Syndrome	Paternal Uniparental Disomy Of Chromosome 14 Uniparental Disomy, Paternal, Chromosome 14 Kos Mca Due To 14q32.2 Maternally Expressed Gene Defect Paternal Uniparental Disomy 14 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion Maternal Del(14)(Q32.2) Maternal Monosomy 14q32.2 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14 Upd(14)Pat
Silver-Russell Syndrome 1	Silver-Russell Syndrome Russell-Silver Syndrome Silver-Russell Dwarfism Rss SRS1 Srs Silver Russell Dwarfism Russell Silver Syndrome Silver Russell Syndrome
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09788	OOEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OOEP	VGNC	VGNC:44125
Rattus norvegicus	OOEP	RGD	RGD:1311103
Macaca mulatta	OOEP	VGNC	VGNC:82201
Bos taurus	OOEP	VGNC	VGNC:32431
Felis catus	OOEP	VGNC	VGNC:97545
Mus musculus	OOEP	MGD	MGI:1915218
Others	OOEP	NCBI