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RPS2 - ribosomal protein S2 Gene

Also Known as S2; LLREP3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6187

About RPS2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,962,058-1,964,826 (from NCBI)

This gene has 17 transcripts (splice variants), 141 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 1267.2), bone marrow (RPKM 851.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS2 Products (1)

mRNA	Protein	Name
NM_002952.4	NP_002943.2	40S ribosomal protein S2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	18573314	GOA
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	16263090	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	18464793	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15473865	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18573314	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16061210	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16061210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS2 Protein Structure

Ribosomal_S5

Ribosomal_S5_C

0
100
200
293 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S2	40S ribosomal protein S4

RPS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RPS2	P15880	PRMT3	Homo sapiens	O60678	Anti Tag CoIP	33961781
Intra	RPS2	P15880	PRMT3	Homo sapiens	O60678	Anti Tag CoIP	25737013
Intra	RPS2	P15880	PRMT3	Homo sapiens	O60678	Y2H Array	32296183
Intra	RPS2	P15880	PRMT3	Homo sapiens	O60678	Y2H Prey Pooling	32296183
Intra	RPS2	P15880	RPS9	Homo sapiens	P46781	Anti Tag CoIP	33961781
Intra	RPS2	P15880	PDCD2	Homo sapiens	Q16342	Anti Tag CoIP	33961781
Intra	RPS2	P15880	PDCD2	Homo sapiens	Q16342	Anti Tag CoIP	28514442
Intra	RPS2	P15880	NAT10	Homo sapiens	Q9H0A0	Anti Tag CoIP	33961781
Intra	RPS2	P15880	NAT10	Homo sapiens	Q9H0A0	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 36	RP36 Retinitis Pigmentosa-36 Retinitis Pigmentosa, Type 36
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Retinitis Pigmentosa 20	RP20 Retinitis Pigmentosa, Type 20
Retinitis Pigmentosa 14	RP14 Retinitis Pigmentosa Juvenile Tulp1-Related Retinitis Pigmentosa-14 Retinitis Pigmentosa, Type 14

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12231	RPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19379	Rps2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25871	Rps2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPS2	VGNC	VGNC:56750
Mus musculus	RPS2	MGD	MGI:105110
Felis catus	RPS2	VGNC	VGNC:80681
Rattus norvegicus	RPS2	RGD	RGD:619887
Others	RPS2	NCBI