NAT10 - N-acetyltransferase 10 Gene

Also Known as ALP; Kre33; NET43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55226

About NAT10

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,105,629-34,146,908 (from NCBI)

This gene has 9 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in lymph node (RPKM 12.6), testis (RPKM 11.9) and 25 other tissues.

Summary

The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

NAT10 Products (2)

mRNA	Protein	Name
NM_001144030.2	NP_001137502.2	RNA cytidine acetyltransferase isoform b
NM_024662.3	NP_078938.3	RNA cytidine acetyltransferase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables N-acetyltransferase activity	EXP EXP: Inferred from Experiment	25411247	GOA
enables mRNA N-acetyltransferase activity	IDA IDA: Inferred from direct assay	30449621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25653167	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	18082603	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	30449621	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	31722219	GOA
involved in regulation of centrosome duplication	IDA IDA: Inferred from direct assay	31722219	GOA
involved in regulation of translation	IDA IDA: Inferred from direct assay	35679869	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleolus	IDA IDA: Inferred from direct assay	18082603	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAT10 Protein Structure

DUF1726

Helicase_RecD

GNAT_acetyltr_2

tRNA_bind_2

0
200
400
600
800
1025 a.a.

Protein Preferred Names	Protein Names
RNA cytidine acetyltransferase	18S rRNA cytosine acetyltransferase

NAT10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAT10	Q9H0A0	RPS2	Homo sapiens	P15880	Crosslink	30021884
Intra	NAT10	Q9H0A0	RPS2	Homo sapiens	P15880	Anti Tag CoIP	33961781
Intra	NAT10	Q9H0A0	THUMPD1	Homo sapiens	Q9NXG2	Anti Bait CoIP	25653167
Intra	NAT10	Q9H0A0	THUMPD1	Homo sapiens	Q9NXG2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

NAT10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81850	NAT10 Antibody (YA1595)	WB, ICC/IF, IP	Human, Rat
HY-P81850A	NAT10 Antibody (YA1595)(PBS only)	WB, ICC/IF, IP	Human, Rat

Related Diseases

Diseases	Alias
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Gastric Cardia Carcinoma	Carcinoma Of Cardia Of Stomach
Microphthalmia, Syndromic 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome MCOPS13 Maine Microphthalmos Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation Syndromic Microphthalmia 13 X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome Microphthalmia, Syndromic, 13 Microphthalmia, Syndromic, Type 13
Muscular Dystrophy, Congenital, Lmna-Related	Congenital Muscular Dystrophy Congenital Muscular Dystrophy Due To Lmna Mutation MDCL L-Cmd Lmna-Related Congenital Muscular Dystrophy Muscular Dystrophy, Congenital Congenital Muscular Dystrophy Lmna-Related Lmna-Related Cmd Cmd Mdc Muscular Dystrophy Congenital Lmna-Related Dystrophy, Muscular, Congenital, Lmna-Related Dystrophy, Muscular, Congenital Hereditary Muscular Dystrophy Congenital Hereditary Muscular Dystrophy Congenital Progressive Muscular Dystrophy Hereditary Progressive Muscular Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16706	Remodelin	Inhibitor	99.84%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAT10	VGNC	VGNC:43627
Macaca mulatta	NAT10	VGNC	VGNC:75046
Bos taurus	NAT10	VGNC	VGNC:31888
Rattus norvegicus	NAT10	RGD	RGD:1306717
Felis catus	NAT10	VGNC	VGNC:63726
Mus musculus	NAT10	MGD	MGI:2138939
Others	NAT10	NCBI