1. Epigenetics
  2. Histone Acetyltransferase
  3. Remodelin

Remodelin 

Cat. No.: HY-16706
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Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.

For research use only. We do not sell to patients.

Remodelin Chemical Structure

Remodelin Chemical Structure

CAS No. : 949912-58-7

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Description

Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. IC50 value: Target: NAT10 inhibitor Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.

Molecular Weight

282.36

Formula

C₁₅H₁₄N₄S

CAS No.
SMILES

N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RemodelinHistone AcetyltransferaseHATsHATInhibitorinhibitorinhibit

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