1. Epigenetics
  2. Histone Acetyltransferase
  3. Remodelin hydrobromide

Remodelin hydrobromide 

Cat. No.: HY-16706A Purity: 99.49%
Handling Instructions

Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity.

For research use only. We do not sell to patients.

Remodelin hydrobromide Chemical Structure

Remodelin hydrobromide Chemical Structure

CAS No. : 1622921-15-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Remodelin hydrobromide:

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Description

Remodelin, a specific inhibitor of N-acetyltransferase NAT10, can ameliorate Hutchinson-Gilford Progeria Syndrom (HGPS) cellular phenotypes. Remodelin acts in a progerin- and FTI-independent pathway, by targeting and inhibiting NAT10[1]. NAT10 is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity[2].

In Vitro

Remodelin blocks invasion and migration of HCC cells in hypoxic conditions[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Remodelin (100 mg/kg; p.o) significantly reduces the loss of subcutaneous adipose tissue that is seen in the HGPS mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LmnaG609G/G609G mice (HGPS mice)[1]
Dosage: 100 mg/kg
Administration: P.o; daily schedule from 3 weeks of age onward, until the end-point (individual weight maxima)
Result: Well-tolerated by both genotypes, with no weight loss.
Molecular Weight

363.28

Formula

C₁₅H₁₅BrN₄S

CAS No.
SMILES

N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 44 mg/mL (121.12 mM)

H2O : 2 mg/mL (5.51 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7527 mL 13.7635 mL 27.5270 mL
5 mM 0.5505 mL 2.7527 mL 5.5054 mL
10 mM 0.2753 mL 1.3763 mL 2.7527 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.49%

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Keywords:

RemodelinHistone AcetyltransferaseHATsHATHGPStelomerasemigrationHCCN-acetyltransferaseInhibitorinhibitorinhibit

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Product Name:
Remodelin hydrobromide
Cat. No.:
HY-16706A
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