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NTNG2 - netrin G2 Gene

Also Known as Lmnt2; NTNG1; NEDBASH; LHLL9381; bA479K20.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84628

About NTNG2

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,161,689-132,244,526 (from NCBI)

This gene has 3 transcripts (splice variants), 282 orthologues, 27 paralogues and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 7.5), brain (RPKM 4.1) and 4 other tissues.

Summary

Predicted to be involved in several processes, including basement membrane assembly; cell morphogenesis involved in differentiation; and regulation of cell projection organization. Located in Flemming body; intercellular bridge; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NTNG2 Products (1)

mRNA	Protein	Name
NM_032536.4	NP_115925.2	netrin-G2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21946559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTNG2 Protein Structure

Laminin_N

Laminin_EGF

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
netrin-G2	laminet 2

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia	NEDBASH
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Schizophrenia 12	Sczd12 Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Partial Fetal Alcohol Syndrome
Hypotonia
St. Louis Encephalitis	Saint Louis Encephalitis Neuroinvasive St. Louis Encephalitis Virus Infection Encephalitis, St. Louis Neuroinvasive Saint Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Neuroinvasive Disease St. Louis Viral Disease Type C Lethargic Encephalitis Encephalitis Type C
Intellectual Developmental Disorder, Autosomal Dominant 41	MRD41 Autosomal Dominant Non-Syndromic Intellectual Disability 41 Mental Retardation, Autosomal Dominant 41 Autosomal Dominant Intellectual Developmental Disorder 41 Autosomal Dominant Mental Retardation 41 Mental Retardation, Autosomal Dominant, Type 41
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09626	NTNG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NTNG2	RGD	RGD:1307089
Bos taurus	NTNG2	VGNC	VGNC:32308
Felis catus	NTNG2	VGNC	VGNC:63907
Macaca mulatta	NTNG2	VGNC	VGNC:75402
Mus musculus	NTNG2	MGD	MGI:2159341
Others	NTNG2	NCBI