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Art. -Nr.: HY-P11826

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T2 peptide-1

T2 peptide-1 is a linear peptide derived from Lumican degradation. T2 peptide-1 exhibits activity against endometrial adhesion progression and ability to inhibit the Lumican−Collagen I interaction. T2 peptide-1 can be used for the research of liver fibrosis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₆₆H₁₀₃N₁₇O₂₅
Molecular Weight:1534.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

T2 peptide-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Collagen I

In Vitro

T2 peptide-1 (10 μM; 1 h) inhibits the Lumican-Collagen I interaction by 12.66^[1].
T2 peptide-1 (10 μM; 24 h) reduces TGF-β1-induced Collagen I expression in human LX2 hepatic stellate cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human LX2 hepatic stellate cells (TGF-β1-stimulated)
Concentration:

10 μM
Incubation Time:

24 h
Result:

Reduced TGF-β1-induced COL1A1 protein levels in LX2 cells to a relative level of ~8 (normalized to GAPDH), which was lower than the TGF-β1-only group (relative level ~10).

In Vivo

T2 peptide-1 (1.0 mg/kg; i.p.; single dose) exhibits rapid elimination following intraperitoneal administration in Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male)^[1]
Dosage:

1.0 mg/kg
Administration:

i.p.; single dose
Result:

Exhibited rapid elimination from circulation.

Chemical Information

Molecular Weight 1534.62
Formel C₆₆H₁₀₃N₁₇O₂₅
Sequence

Tyr-Leu-Asp-Asn-Asn-Lys-Ile-Ser-Asn-Ile-Pro-Asp-Glu
Sequence Shortening

YLDNNKISNIPDE
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wei X, et al. Structure-Based Development of a Novel Macrocyclic Peptide to Disrupt the Lumican-Collagen I Interaction in Liver Fibrosis. J Med Chem. 2025;68(23):25523-25538. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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