1,4-Bis(trifluoromethyl)benzene
1,4-Bis(trifluoromethyl)benzene is an organic compound of great significance in the study of metalation reactions in organic synthesis.
For research use only. We do not sell to patients.
- CAS No.: 433-19-2
- Formula: C8H4F6
- Molecular Weight:214.11
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 433-19-2
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Appearance Liquid (Density: 1.368±0.06 g/cm3)
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Molecular Weight 214.11
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Formula C8H4F6
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Color Colorless to light yellow
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SMILES
FC(F)(F)C1=CC=C(C(F)(F)F)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 100 mg/mL (467.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Elslager EF, et al. Antimalarial and antischistosomal effects of alpha,alpha,alpha,alpha',alpha',alpha'-hexachloroxylene derivatives and related halogenated hydrocarbons. J Med Chem. 1970 May;13(3):542-4. [Content Brief]
[2]. Liang J, et al. Mechanism of Lithium Diisopropylamide-Mediated Ortholithiation of 1,4-Bis(trifluoromethyl)benzene under Nonequilibrium Conditions: Condition-Dependent Rate Limitation and Lithium Chloride-Catalyzed Inhibition. J Am Chem Soc. 2015 May 20;137(19):6292-303. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6705 mL | 23.3525 mL | 46.7050 mL | 116.7624 mL |
| 5 mM | 0.9341 mL | 4.6705 mL | 9.3410 mL | 23.3525 mL | |
| 10 mM | 0.4670 mL | 2.3352 mL | 4.6705 mL | 11.6762 mL | |
| 15 mM | 0.3114 mL | 1.5568 mL | 3.1137 mL | 7.7842 mL | |
| 20 mM | 0.2335 mL | 1.1676 mL | 2.3352 mL | 5.8381 mL | |
| 25 mM | 0.1868 mL | 0.9341 mL | 1.8682 mL | 4.6705 mL | |
| 30 mM | 0.1557 mL | 0.7784 mL | 1.5568 mL | 3.8921 mL | |
| 40 mM | 0.1168 mL | 0.5838 mL | 1.1676 mL | 2.9191 mL | |
| 50 mM | 0.0934 mL | 0.4670 mL | 0.9341 mL | 2.3352 mL | |
| 60 mM | 0.0778 mL | 0.3892 mL | 0.7784 mL | 1.9460 mL | |
| 80 mM | 0.0584 mL | 0.2919 mL | 0.5838 mL | 1.4595 mL | |
| 100 mM | 0.0467 mL | 0.2335 mL | 0.4670 mL | 1.1676 mL |
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