Hypericaceae

3-Isomangostin hydrate (Compound 17) is an xanthone that can be isolated from Cratoxylum formosum ssp. pruniflorum and exhibits antibacterial activity.

Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research.

3,8-Dihydroxy-1,2-dimethoxyxanthone is a xanthone compound found in the leaves and stems of Hypericum geminiflorum.

5,7-Dihydroxy-2-isopropylchromone (Compound 9) is a chromone derivative. 5,7-Dihydroxy-2-isopropylchromone can be isolated from the leaves of Hypericum ascyron.

Dulcisxanthone B is an antioxidant agent with free radical scavenging against DPPH (IC₅₀ of 0.39 mM) and lipid peroxidation inhibition (IC₅₀ of 024 μM).

Petiolin G is a natural phenolic compound.

Hyperwightin B is a natural flavonoid.

Hyperwightin D is a natural phenolic compound.

Hyperwightin E is a natural phenolic compound.

4a-Demethoxysampsone B is a natural phenolic compound.

Pruniflorone R is a natural xanthone.

3,6-Dihydroxy-1,7-dimethoxyxanthone is a natural xanthone.

1-Isomangostin hydrate is a semi-synthetic cyclized xanthone derivative of α-mangostin (HY-N0328), exhibiting weak cytotoxicity against HT-29 human colon cancer cells (ED₅₀ > 20 μM). 1-Isomangostin hydrate can be used in research on colon cancer and other tumors. The natural precursor of 1-isomangostin hydrate, α-mangostin, is derived from the stem of Cratoxylum cochinchinense (a plant of the Cratoxylum genus in the Clusiaceae family).

Sampsone B is a dihydrodibenzodioxinone-type antibacterial agent with a minimum inhibitory concentration (MIC) of ≥128 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Sampsone B can be naturally extracted from the aerial parts (stems and leaves) of Hypericum sampsonii.

3-Isomangostin hydrate formate is a derivative of mangostin that can be isolated from Garcinia mangostana Linn. (Guttiferae).

4-Hydroxy-2,3-dimethoxyxanthone is an anti-inflammatory agent isolated from Hypericum oblongifolium (Hypericum oblongifolium Wall.).

Hyperxanthone is a pyranoxanthone compound isolated from Hypericum sampsonii Hance.

Toxyloxanthone B is a xanthone.

Hyperwightin C is a benzophenone glycoside. Hyperwightin C has not shown any significant neuroprotective effect.

Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant K_d of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research.