IPMK - inositol polyphosphate multikinase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 253430

About IPMK

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,191,517-58,267,894 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 5.2), small intestine (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

IPMK Products (1)

mRNA	Protein	Name
NM_152230.5	NP_689416.1	inositol polyphosphate multikinase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables flavonoid binding	IDA IDA: Inferred from direct assay	30624931	GOA
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	IMP IMP: Inferred from mutant phenotype	29883610	GOA
enables inositol-1,4,5-trisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	30624931	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in inositol trisphosphate metabolic process	IDA IDA: Inferred from direct assay	30624931	GOA
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	29883610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPMK Protein Structure

IPK

0
100
200
300
416 a.a.

Protein Preferred Names	Protein Names
inositol polyphosphate multikinase	inositol 1,3,4,6-tetrakisphosphate 5-kinase

IPMK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IPMK	Q8NFU5	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	IPMK	Q8NFU5	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hereditary Neuroendocrine Tumor Of Small Intestine	Hereditary Neuroendocrine Tumor Of Small Bowel
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153530	LI-2242	Inhibitor	98.83%	Unkown
HY-175476	UNC7437	Inhibitor	99.58%	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-RS06865	IPMK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21357	Ipmk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27876	Ipmk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IPMK	MGD	MGI:1916968
Bos taurus	IPMK	VGNC	VGNC:30240
Macaca mulatta	IPMK	VGNC	VGNC:106064
Rattus norvegicus	IPMK	RGD	RGD:620954
Others	IPMK	NCBI