2. Metabolic Enzyme/Protease PI3K/Akt/mTOR
  3. IPK Superfamily
  4. UNC7437

UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC50 value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP4, InsP5, and InsP6 in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models.

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UNC7437

UNC7437 Chemical Structure

CAS No. : 2967647-41-0

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Based on 1 publication(s) in Google Scholar

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Description

UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC50 value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP4, InsP5, and InsP6 in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models[1].

In Vitro

UNC7437 (400 nM, 48 h) shows significant anti-proliferative activity against human U251-MG glioblastoma cells[1].
UNC7437 (400 nM, 48 h) effectively inhibits inositol phosphate synthesis in human U251-MG glioblastoma cells, significantly decreasing the accumulation of InsP4, InsP5, and InsP6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC7437 Related Antibodies
Molecular Weight

293.32

Formula

C18H15NO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)/C=C/C1=CC2=C(C3=CC(C)=CC(C)=C3)ON=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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UNC7437 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC74372967647-41-0UNC 7437UNC-7437IPK SuperfamilyInositiol Polyphosphate Kinase (IPK) Superfamilyinositol phosphate multikinaseglioblastomInhibitorinhibitorinhibit

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