Antioxidant agent-8
Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect.
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- Formule: C13H12O5
- Masse moléculaire:248.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Antioxidant agent-8 (compound 30) (50 µM; 24 h) selectively chelates with Cu2+, Fe2+, Zn2+, Fe3+ and Al3+ metal ions, significantly inhibits self- and Cu2+-induced Aβ1-42 fibril aggregation and disaggregation[1].
Antioxidant agent-8 (2.5, 5 and 10 µM; 24 h) promotes BV-2 cells to clear Aβ1-42, reduces Aβ1-42 induced apoptosis and protects nerves with concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse microglia BV-2 cells.
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Concentration:2.5, 5 and 10 µM.
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Incubation Time:24 h.
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Result:Reduced the expression level of Aβ1-42 in cells.
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Cell Line:Mouse microglia BV-2 cells.
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Concentration:2.5, 5 and 10 µM.
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Incubation Time:24 h.
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Result:Significantly reduced Aβ1-42 induced apoptosis (cell apoptosis rate were below 30%).
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Cell Line:Mouse microglia BV-2 cells.
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Concentration:2.5, 5 and 10 µM.
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Incubation Time:24 h.
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Result:Promoted cell viability and the cell survival was 75.50 % (10 µM).
Antioxidant agent-8 (2000 mg/kg; i.g.; single dose) exhibits biosafety[1].
Antioxidant agent-8 (20 mg/kg; p.o.; once daily for 25 d) significantly improves anxiety, memory impairment and cognitive impairment caused by Scopolamine (HY-N0296)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats[1].
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Dosage:15 mg/kg.
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Administration:Intragastric administration; single dose.
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Result:Appeared in plasma and hippocampus at 0.083, 0.167, 0.25, 0.5, 1, 2 and 4 hours after administration, and then gradually gathered in hippocampus.
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Animal Model:Mice[1].
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Dosage:2000 mg/kg.
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Administration:Intragastric administration; single dose.
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Result:Showed insignificant toxic and side effects on heart, liver, spleen and brain.
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Animal Model:SCOP-induced cognitive impairment in ICR mice (25-28 g)[1].
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Dosage:20 mg/kg.
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Administration:Oral gavage; from day 7 to day 31, after 30 min of SCOP administration.
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Result:Improved animal behavior, learning and memory.
Chemical Information
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Masse moléculaire 248.23
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Formule C13H12O5
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SMILES
O=C1CCOC(/C=C/C2=CC=C(C(O)=C2)O)=C1O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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