Ercc2 - excision repair cross-complementing rodent repair deficiency, complementation group 2 Gene

Also Known as XPD; CXPD; Ercc-2; RCO015; Mhdarco15

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13871

Summary

Predicted to enable several functions, including 5'-3' DNA helicase activity; protein C-terminus binding activity; and protein N-terminus binding activity. Acts upstream of or within several processes, including animal organ development; neurogenesis; and nucleic acid metabolic process. Located in nucleus. Is expressed in central nervous system; eye; hair follicle; and liver. Used to study photosensitive trichothiodystrophy and xeroderma pigmentosum group D. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic Cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc2 Products (2)

mRNA Protein Name
NM_001363981.1 NP_001350910.1 general transcription and DNA repair factor IIH helicase subunit XPD isoform 2
NM_007949.5 NP_031975.2 general transcription and DNA repair factor IIH helicase subunit XPD isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Références Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within UV protection IMP
IMP: Inferred from mutant phenotype
9651581 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within central nervous system myelin formation IMP
IMP: Inferred from mutant phenotype
17952069 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within embryonic cleavage IMP
IMP: Inferred from mutant phenotype
9426063 MGI
acts upstream of or within erythrocyte maturation IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
9651581 MGI
acts upstream of or within hair cell differentiation IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within hair cycle process IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within hair follicle maturation IMP
IMP: Inferred from mutant phenotype
9651581 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
17554309 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18545656 MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
18545656 MGI
acts upstream of or within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
IMP: Inferred from mutant phenotype
23562818 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
9651581 MGI
acts upstream of or within positive regulation of DNA binding IMP
IMP: Inferred from mutant phenotype
17952069 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
11950998 MGI
acts upstream of or within ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
23562818 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
9651581 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
17020410 MGI
acts upstream of or within transcription elongation by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
23562818 MGI
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
17952069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

general transcription and DNA repair factor IIH helicase subunit XPD

  • DNA excision repair protein ERCC-2

  • DNA repair protein complementing XP-D cells

  • TFIIH basal transcription factor complex helicase XPD subunit

  • xeroderma pigmentosum group D-complementing protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04479 ERCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22491 Ercc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29014 Ercc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc2 NCBI NCBI:2068