ARHGAP26 - Rho GTPase activating protein 26 Gene

Also Known as GRAF; GRAF1; OPHN1L; OPHN1L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23092

About ARHGAP26

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,770,377-143,229,011 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 76 phenotypes. Ubiquitous expression in brain (RPKM 7.0), gall bladder (RPKM 4.5) and 24 other tissues.

Summary

Interaction of a cell with the extracellular matrix triggers Integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

ARHGAP26 Products (3)

mRNA	Protein	Name
NM_001135608.3	NP_001129080.1	rho GTPase-activating protein 26 isoform b
NM_001349547.2	NP_001336476.1	rho GTPase-activating protein 26 isoform c
NM_015071.6	NP_055886.1	rho GTPase-activating protein 26 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	18954304	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11432776	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	38081847	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in mitophagy	IDA IDA: Inferred from direct assay	38081847	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	32344433	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	32344433	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	38081847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP26 Protein Structure

IMD

RhoGAP

SH3_9

0
200
400
600
814 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 26	GTPase regulator associated with focal adhesion kinase pp125(FAK)

ARHGAP26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ARHGAP26	Q9UNA1	PKN3	Homo sapiens	Q6P5Z2	Pull Down	11432776
Intra	ARHGAP26	Q9UNA1	CDC42EP2	Homo sapiens	O14613	Validated Y2H	25416956
Intra	ARHGAP26	Q9UNA1	CDC42EP2	Homo sapiens	O14613	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Diffuse Gastric Cancer	Hereditary Diffuse Gastric Adenocarcinoma Hereditary Diffuse Gastric Cancer Signet Cell Adenocarcinoma Signet Ring Cell Carcinoma Signet Ring Cell Gastric Carcinoma Signet Ring Gastric Carcinoma Fdgc Familial Diffuse Cancer Of Stomach Familial Diffuse Gastric Cancer Gastric Cancer, Familial Diffuse Gastric Cancer, Hereditary Diffuse Hdgc Hereditary Diffuse Cancer Of Stomach Diffuse Gastric Cancer Syndrome Cancer, Gastric, Diffuse Carcinoma, Signet Ring Cell Gastric Signet Ring Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00926	ARHGAP26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGAP26	RGD	RGD:1310923
Canis familiaris	ARHGAP26	VGNC	VGNC:38054
Macaca mulatta	ARHGAP26	VGNC	VGNC:69846
Mus musculus	ARHGAP26	MGD	MGI:1918552
Bos taurus	ARHGAP26	VGNC	VGNC:26084
Felis catus	ARHGAP26	VGNC	VGNC:59883