PKN3 - protein kinase N3 Gene

Also Known as UTDP4-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29941

About PKN3

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,702,503-128,720,916 (from NCBI)

This gene has 3 transcripts (splice variants), 291 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 3.9), lung (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PKN3 Products (2)

mRNA Protein Name
NM_001317926.2 NP_001304855.1 serine/threonine-protein kinase N3 isoform 2
NM_013355.5 NP_037487.2 serine/threonine-protein kinase N3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11432776 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell migration IDA
IDA: Inferred from direct assay
21754995 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKN3 Protein Structure

HR1

HR1: Hr1 repeat (20 - 79)

HR1

HR1: Hr1 repeat (107 - 171)

HR1

HR1: Hr1 repeat (180 - 247)

Pkinase

Pkinase: Protein kinase domain (560 - 817)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (841 - 884)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 889 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase N3

  • protein kinase PKN-beta

PKN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Pull Down
32707033
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Anti Tag CoIP
11432776
Intra
PKN3 Q6P5Z2 ARHGAP26 Homo sapiens Q9UNA1
Y2H
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Pull Down
32707033
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Y2H
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Anti Tag CoIP
11432776
Intra
PKN3 Q6P5Z2 ARHGAP10 Homo sapiens A1A4S6
Pull Down
11432776
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
PKN3 Q6P5Z2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PKN3 Q6P5Z2 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PKN3 Q6P5Z2 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nonarteritic Anterior Ischemic Optic Neuropathy

  • Anterior Ischemic Optic Neuropathy

  • Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To

  • NAION

  • Non-Arteritic Anterior Ischemic Optic Neuropathy

  • Ischemic Optic Neuropathy

  • Aion

  • Optic Neuropathy, Ischemic

  • Naion, Susceptibility To

  • Optic Neuropathy, Anterior Ischemic

  • Optic Neuropathy, Anterior Ischemic, Susceptibility To

  • Non-Arteritic Anterior Ischaemic Optic Neuropathy

  • Nonarteritic Anterior Ischaemic Optic Neuropathy

  • Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To

  • Ion - [Ischemic Optic Neuropathy]

  • Neuropathic Ischaemia Of N.Opticus

  • Ischaemic Neuropathy Of Optic Nerve
Gastrointestinal Neuroendocrine Tumor

  • Gastrointestinal Neuroendocrine Tumour

  • Malignant Gastrointestinal Neuroendocrine Tumor

  • Malignant Gastrointestinal Neuroendocrine Tumour

  • Digestive System Neuroendocrine Neoplasm

  • Digestive System Neuroendocrine Tumor
Pachyonychia Congenita 1

  • Pachyonychia Congenita

  • Jadassohn-Lewandowsky Syndrome

  • Pachyonychia Congenita Syndrome

  • PC1

  • Pachyonychia Congenita, Jadassohn-Lewandowsky Type

  • Congenital Pachyonychia

  • Pachyonychia Congenita, Type 1

  • Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

  • Jadassohn-Lewandowsky Syndrome, Formerly

  • Jackson-Lawler Type Pachyonychia Congenita

  • Pachyonychia Congenita Type 1

  • Jackson-Lawler Syndrome

  • Jadassohn-Lewandowski Syndrome

  • Pc

  • Pachyonychia Congenita Jackson-Lawler Type

  • Pachyonychia Congenita Jadassohn-Lewandowsky Type

  • Pachyonychia Congenita Jackson Lawler Type

  • Pc-1

  • Pachyonychia Congenita, Jadassohn Lewandowsky Type

  • Pachyonychia Congenita, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-153482 ATU027 99.22% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-169789 PKN3-IN-1 98.97% Unkown
HY-153482A ATU027 sodium Inhibitor 99.22% Unkown
HY-RS10608 PKN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18633 Pkn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25119 Pkn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PKN3 RGD RGD:1305921
Felis catus PKN3 VGNC VGNC:64195
Bos taurus PKN3 VGNC VGNC:32947
Canis familiaris PKN3 VGNC VGNC:44613
Macaca mulatta PKN3 VGNC VGNC:75824
Mus musculus PKN3 MGD MGI:2388285
Others PKN3 NCBI