PKN3 - protein kinase N3 Gene

Homo sapiens

Also known as UTDP4-1

Gene ID: 29941 | Gene type: protein coding

About PKN3

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,702,503-128,720,916 (from NCBI)

This gene has 3 transcripts (splice variants), 291 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 3.9), lung (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PKN3 Products(2)

mRNA	Protein	Name
NM_001317926.2	NP_001304855.1	serine/threonine-protein kinase N3 isoform 2
NM_013355.5	NP_037487.2	serine/threonine-protein kinase N3 isoform 1

PKN3 Protein Structure

HR1

Pkinase

Pkinase_C

0
200
400
600
800
889 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase N3

protein kinase PKN-beta

Related Diseases

Diseases

Alias

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy	Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
NAION	Non-Arteritic Anterior Ischemic Optic Neuropathy
Ischemic Optic Neuropathy	Aion
Optic Neuropathy, Ischemic	Naion, Susceptibility To
Optic Neuropathy, Anterior Ischemic	Optic Neuropathy, Anterior Ischemic, Susceptibility To
Non-Arteritic Anterior Ischaemic Optic Neuropathy	Nonarteritic Anterior Ischaemic Optic Neuropathy
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To	Ion - [Ischemic Optic Neuropathy]
Neuropathic Ischaemia Of N.Opticus	Ischaemic Neuropathy Of Optic Nerve

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1		/	Unkown
HY-153482	ATU027		/	Unkown
HY-153482A	ATU027 sodium	Inhibitor	/	Unkown
HY-RS10608	PKN3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PKN3	RGD	RGD:1305921
Felis catus	PKN3	VGNC	VGNC:64195
Bos taurus	PKN3	VGNC	VGNC:32947
Canis familiaris	PKN3	VGNC	VGNC:44613
Macaca mulatta	PKN3	VGNC	VGNC:75824
Mus musculus	PKN3	MGD	MGI:2388285

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