eALM1192
eALM1192 is a selective mTOR kinase inhibitor (IC50 = 2.3 nM) that also inhibits DNA-PK (IC50 = 84 nM), PI3Kα, and PKN3, with 37-fold selectivity for mTOR over DNA-PK. eALM1192 exhibits antiproliferative activity against cancer cell lines and colorectal cancer cell lines. eALM1192 can be used for colorectal cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3134761-90-0
- Formula: C23H23N7O3
- Molecular Weight:445.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
mTOR 2.3 nM (IC50) |
DNA-PK 84 nM (IC50) |
PI3Kα |
PKN3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SW48 | EC50 |
5.6 nM
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Antiproliferative activity against human SW48 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human SW48 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
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D6MD00572A |
| HCT-116 | EC50 |
49 nM
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Antiproliferative activity against human HCT116 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human HCT116 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
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D6MD00572A |
| SW480 | EC50 |
63 nM
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Antiproliferative activity against human SW480 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
Antiproliferative activity against human SW480 colorectal cancer cells assessed as reduction in cell viability incubated for 5 days by PrestoBlue assay.
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D6MD00572A |
In Vitro
2w (eALM1192) (1-10000 nM; 5 days) exhibits potent low-nanomolar antiproliferative activity across SW48, HCT116 and SW480 colorectal cancer cell lines[1].
eALM1192 (1 μM) acts as a highly selective inhibitor, demonstrating potent activity (determined as residual activity at 1 μM) primarily against MTOR, DNAPK, and PIK3CA/PIK3R1.
2w (eALM1192) (0.09-3000 nM) is a potent mTOR inhibitor with an IC50 of 2.3 nM and 37-fold selectivity over DNA-PK[1].
2w (eALM1192) (1 µM; 0-45 min) demonstrates excellent metabolic stability with a half-life of 109 min in human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3134761-90-0
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Molecular Weight 445.47
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Formula C23H23N7O3
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SMILES
O=C(N1CCC(CN2C=C(C3=CC=C(OC(N)=N4)C4=C3)C5=C(N)N=CN=C52)CC1)OCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
eALM1192 Related Classifications
HY-189486 Related Classifications
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