3134761-90-0
3134761-90-0
Chemical Structure
eALM1192
- CAS No.: 3134761-90-0
- Formula:C23H23N7O3
- Molecular Weight:445.47
InChIKey: NNKUZUUMZPLUSF-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CN2C=C(C3=CC=C(OC(N)=N4)C4=C3)C5=C(N)N=CN=C52)CC1)OCC#C
Biological Activity: eALM1192 is a selective mTOR kinase inhibitor (IC50 = 2.3 nM) that also inhibits DNA-PK (IC50 = 84 nM), PI3Kα, and PKN3, with 37-fold selectivity for mTOR over DNA-PK. eALM1192 exhibits antiproliferative activity against cancer cell lines and colorectal cancer cell lines. eALM1192 can be used for colorectal cancer research[1].
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eALM1192 | eALM1192 is a selective mTOR kinase inhibitor (IC50 = 2.3 nM) that also inhibits DNA-PK (IC50 = 84 nM), PI3Kα, and PKN3, with 37-fold selectivity for mTOR over DNA-PK. eALM1192 exhibits antiproliferative activity against cancer cell lines and colorectal cancer cell lines. eALM1192 can be used for colorectal cancer research. | |||||||||||||||||||||
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